五项生化指标检测在肝硬化诊断中的临床价值

Clinical value of detection of five biochemical indicators in the diagnosis of liver cirrhosis

目的探讨五项生化指标检测在肝硬化诊断中的临床价值。方法选择2017年1月至2018年12月我院收治的已明确诊断为病毒性肝硬化的300例患者为研究组。依照Child-Pugh分级方法,将研究组患者分为甲组(Child-Pugh得分<7分,100例)、乙组(Child-Pugh得分7~9分,100例)、丙组(Child-Pugh得分≥10分,100例)。另选择同时间段来我院进行常规体检的100例健康者为对照组。比较不同组别之间的ADA、GGT、TBA、hs-CRP及ChE水平。结果研究组血清ADA、GGT、TBA、hs-CRP水平均明显高于对照组,ChE水平明显低于对照组(P<0.05)。甲组的血清ADA、GGT、TBA、hs-CRP水平明显高于乙组和丙组,ChE水平明显低于乙组和丙组(P<0.05);乙组的血清ADA、GGT、TBA、hs-CRP水平明显高于丙组,ChE水平明显低于丙组(P<0.05)。结论 ADA、GGT、TBA、hs-CRP及ChE的检测有助于临床对肝硬化的早期诊断,并为肝硬化严重程度的评估提供重要参考依据。

Objective To explore the clinical value of detection of five biochemical indicators in the diagnosis of liver cirrhosis. Methods A total of 300 patients who had been diagnosed with viral liver cirrhosis admitted in our hospital from January 2017 to December 2018 were selected as study group. According to the Child-Pugh classification method, the study group patients were divided into group A(Child-Pugh score<7 points, 100 cases), group B(Child-Pugh score 7-9 points, 100 cases) and group C(Child-Pugh score≥10 points, 100 cases). Another 100 healthy persons who were admitted in our hospital for regular physical examination at the same time were selected as control group. The levels of ADA, GGT,TBA, hs-CRP and ChE among the different groups were compared. Results The levels of serum ADA, GGT, TBA and hsCRP in the study group were significantly higher than those in the control group, the ChE level was significantly lower than that in the control group(P<0.05). The levels of serum ADA, GGT, TBA and hs-CRP in the group A were significantly higher than those in the group B and group C, the ChE level was significantly lower than that in the group B and group C(P<0.05);the levels of serum ADA, GGT, TBA, hs-CRP in the group B were significantly higher than those of the group C,the ChE level was significantly lower than that of the group C(P<0.05). Conclusion The detection of ADA, GGT, TBA, hsCRP and ChE is helpful for the early diagnosis of liver cirrhosis in clinical. It can provide an important reference for the assessment of the severity of liver cirrhosis.