糖尿病足慢性溃疡的治疗方法新进展

New progress on treatment for chronic ulcer of diabetic foot

糖尿病足是糖尿病最严重的并发症之一。糖尿病足足部感染导致创面经久不愈,严重者可导致骨髓炎、骨质破坏,具有较高的截肢可能。临床上,随着对糖尿病足慢性溃疡认识及治疗水平的提高,近年来涌现出各种治疗糖尿病足慢性感染性溃疡的方式。除传统的内科治疗通过药物控制血糖和感染的措施外,清创术、新型创面敷料、创面负压吸引术、高压氧疗、利用自体富含血小板凝胶和表皮生长因子进行组织修复,以及光动力疗法等治疗方式纷纷出现。本文通过对一些临床上糖尿病足慢性感染性溃疡治疗方法的进展进行综述,为今后治疗慢性难愈合糖尿病足创面提供相应的参考。

Diabetic foot is one of the most serious complications of diabetes.Diabetic foot infections will cause the wound surface unhealing for a long time,and even result in osteomyelitis or bone destruction if serious,which shows high risk of amputation.Clinically,there have been various treatments for the chronic infectious ulcer of diabetic foot emerging in recent years with the improvement in the understanding and treatment technology of chronic ulcer of diabetic foot.In addition to the traditional treatments to control blood glucose and infection through drugs,a lot of treatments have also emerged,such as debridement,new wound dressings,wound surface vacuum aspiration,hyperbaric oxygen therapy,tissue repair with autologous platelet-rich gel and epidermal growth factor,photodynamic therapy and so on.The progress on the treatment of chronic infectious ulcer of diabetic foot clinically has been briefly reviewed in this paper,thus providing a reference for the treatment of chronic intractable diabetic foot wounds in the future.