腰椎间盘突出症患者血清细胞因子的表达及与疼痛程度的关系探讨

Investigation of the relationship between serum cytokines and pain level in patients with lumbar disc herniation

目的探讨腰椎间盘突出症患者血清细胞因子的表达及与疼痛程度的关系。方法选取2016年1月-2018年1月我院收治确诊的110例腰椎间盘突出症患者作为观察组,根据VAS评分分为轻度疼痛组(n=45)、中度疼痛组(n=41)、重度疼痛组(n=24),另选取同期来我院进行体检的30例健康者作为对照组。测定并比较各组丙二醇(MDA)、血栓素(TX)、前列腺素E(PGE)、降钙素(CA)、肿瘤坏死因子(TNF)、超氧化物歧化酶(SOD)、白细胞介素-6(IL-6)、内皮素(ET)等血清细胞因子水平,分析其含量与患者疼痛程度的关系。结果观察组患者的MDA、TX、PGE、CA、TNF、SOD、IL-6、ET等血清细胞因子水平均明显高于对照组(P<0.05);观察组中,各亚组血清细胞因子水平的比较,重度疼痛组>中度疼痛组>轻度疼痛组,差异均有统计学意义(P<0.05)。Logistic回归分析显示,腰椎间盘突出症患者血清细胞因子中的MDA、TX、PGE、CA、TNF、SOD、IL-6、ET表达与其疼痛程度均密切相关(P<0.05)。结论腰椎间盘突出症患者的血清细胞因子表达与其疼痛程度密切相关,临床中应密切关注该类指标的变化。

Objective To investigate the relationship between serum cytokines and pain level in patients with lumbar disc herniation.Methods From January 2016 to January 2018,110 cases of lumbar disc herniation diagnosed in our hospital in were selected as the observation group.Visual analogue scale(VAS)was used to evaluate pain scores in all patients,according to the score,the patients were divided into mild pain group(n=45),moderate pain group(n=41)and severe pain group(n=24).Another 30 healthy persons in our hospital for a physical examination during the same period were selected as the control group.The levels of serum cytokines such as malondialdehyde(MDA),thromboxane(TX),prostaglandin E(PGE),calcitonin(CA),tumor necrosis factor(TNF),superoxide dismutase(SOD),interleukin-6(IL-6),endothelin(ET)and other serum cytokine levels were measured and compared,the relationship between serum cytokines and lumbar disc herniation pain was analyzed.Results The serum levels of cytokines such as MDA,TX,PGE,CA,TNF,SOD,IL-6 and ET in the observation group were significantly higher than those in the control group(P<0.05).Serum cytokine levels of each subgroup were compared,the severe pain group>the moderate pain group>the mild pain group,and the difference was statistically significant(P<0.05).Further Logistic regression analysis showed that the levels of MDA,TX,PGE,CA,TNF,SOD,IL-6 and ET in the serum of patients with lumbar disc herniation were closely related to the degree of pain(P<0.05).Conclusion The expression of serum cytokines in patients with lumbar disc herniation is closely related to the degree of pain,in clinical practice,we should pay close attention to the changes of these indicators.