氯吡格雷联合阿司匹林对冠心病患者PCI术后凝血功能和炎症因子的影响

Effect of clopidogrel combined with aspirin on coagulation function and inflammatory factors in patients with coronary heart disease after PCI

目的探讨氯吡格雷联合阿司匹林对冠心病患者冠状动脉介入手术(PCI)术后凝血功能和炎症因子的影响。方法将2018年1月-12月在我院就诊的62例冠心病患者根据治疗方法不同分为对照组(n=28例)和试验组(n=34例),对照组PCI术后采用氯吡格雷治疗,试验组行氯吡格雷联合阿司匹林治疗。对比分析2组患者凝血功能、炎症因子及不良反应发生率。结果在治疗后,2组患者APTT、PT均显著高于治疗前(P<0.05),且试验组患者高于对照组(P<0.05)。治疗前后2组患者炎症指标IL-6、MPO差异均不显著(P>0.05),治疗后2组患者IL-6、MPO均显著低于本组治疗前(P<0.05)。对照组不良反应发生率为10.71%,试验组不良反应发生率为14.71%,差异不显著(P<0.05)。结论对冠心病患者PCI术后给予氯吡格雷联合阿司匹林治疗,可有效改善凝血功能,具有推广价值。

Objective To investigate the effect of clopidogrel combined with aspirin on coagulation function and inflammatory factors in patients with coronary heart disease after PCI. Methods From January to December 2018,62 patients with coronary heart disease treated in our hospital were divided into control group(n=28) and experimental group(n=34)according to different treatment methods. The control group was treated with clopidogrel after PCI,while the experimental group was treated with clopidogrel combined with aspirin. The incidence of coagulation function,inflammatory factors and adverse reactions in the two groups were compared and analyzed. Results After treatment,APTT and PT in both groups were significantly greater than before treatment(P<0.05). After treatment,APTT and PT in the experimental group were significantly greater than those in the control group(P<0.05). There were no significant differences in inflammatory indicators IL-6 and MPO between the two groups before and after treatment(P>0.05).After treatment,IL-6 and MPO in both groups were significantly lower than before treatment(P<0.05). The incidence of adverse reactions was 10.71% in the control group and 14.71% in the experimental group,with no significant difference(P<0.05). Conclusion Clopidogrel combined with aspirin can effectively improve the coagulation function of patients with coronary heart disease after PCI,and has the value of clinical application.