高剂量阿托伐他汀在造影剂肾病预防中的应用价值分析

Application Value and Curative Effect of Atto Vastatin in Prevention of Contrast Agent Nephropathy

目的探讨阿托伐他汀在造影剂肾病预防中的应用价值。方法选取2015年8月至2017年12月在我院进行冠状动脉介入的患者108例,根据使用阿托伐他汀剂量不同分为对照组和观察组。对照组患者口服常规剂量阿托伐他汀,观察组患者口服高剂量他汀,分析两组患者预防造影剂肾病的临床价值。结果观察组术后发生造影剂肾病2(3.70%)例,对照组发生10(18.52%)例,两组术后造影剂肾病发生率比较,差异有统计学意义(P<0.05)。术前,两组患者肾功能指标、hs-CRP、MDA、SOD水平比较,差异无统计学意义(P>0.05)。术后24h、72h,观察组患者BUN、β2-MG、NGAL、GysC、hs-CRP、MDA水平低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05)。观察组患者一个月内心脏不良事件发生率为3.70%,对照组为14.81%,观察组患者心脏不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论冠状动脉介入术前给予高剂量阿托伐他汀可降低术后造影剂肾病的发生率,减轻氧化应激反应和术后急性肾功能损伤。

Objective To investigate the value and efficacy of Atto vastatin in the prevention of contrast agent nephropathy. Methods 108 patients who underwent coronary intervention in our hospital from August 2015 to December 2017 were divided into control group and observation group according to the dosage of Atto vastatin.The patients in the control group were given routine dose of Atto vastatin and the patients in the observation group were given high dose of statins.The clinical value of preventing contrast agent nephropathy between the two groups was analyzed.Results The incidence of contrast agent nephropathy was significantly higher in the observation group than in the control group( P<0.05).Before operation,there was no significant difference in the level of SOD between the two groups( P>0.05).At 24 hours and 72 hours after operation,the MDA levels of Bunn,β2-MG,NGAL,GysC,hs-CRP in the observation group were significantly lower than those in the control group( P<0.05),and the levels of SOD in the control group were significantly higher than those in the control group( P<0.05).The incidence of adverse cardiac events was 3.70 in the observation group and 14.81 in the control group.The incidence of adverse cardiac events in the observation group was lower than that in the control group( P<0.05).Conclusion High dose Atto vastatin before coronary intervention can reduce the incidence of postoperative contrast agent nephropathy,reduce oxidative stress,and alleviate acute renal function injury after coronary intervention.