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利拉鲁肽对初发2型糖尿病伴肥胖患者代谢紊乱的调节作用 被引量:3

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摘要 目的:分析利拉鲁肽对初发2型糖尿病伴肥胖患者代谢紊乱的调节作用。方法:选取河南科技大学第一附属医院2017年2月至2018年12月收治的初发2型糖尿病伴肥胖患者102例,将其随机分为对照组和观察组,各51例,给予对照组患者二甲双胍药物治疗,给予观察组患者利拉鲁肽治疗,观察并比较两组患者的临床治疗效果。结果:观察组患者的空腹血糖(FPG)、空腹胰岛素(FIN)、空腹C肽(F–CP)指标均低于对照组,差异具有统计学意义(P <0.05);观察组患者的血清总胆固醇(TC)、三酰甘油(TG)水平低于对照组,高密度脂蛋白胆固醇(HDL–C)水平高于对照组,差异具有统计学意义(P <0.05);观察组患者的C反应蛋白(CRP)、白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF–α)水平均低于对照组,差异具有统计学意义(P <0.05)。结论:临床上治疗初发2型糖尿病伴肥胖患者时,采用利拉鲁肽治疗,不但能够有效改善患者的糖脂代谢水平,还能降低机体的炎症反应。
作者 朱超霞
出处 《深圳中西医结合杂志》 2019年第16期156-157,共2页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
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