Krüppel样因子4和驱动蛋白家族20A在胃癌组织的表达及其临床意义

Expression and clinical significance of krüppel-like factor 4 and kinesin family member 20A in gastric carcinoma

目的探讨Krüppel样因子4(KLF4)和驱动蛋白家族20A(KIF20A)在胃癌组织的表达水平及两者与胃癌临床病理参数的关系.方法收集69例胃癌患者胃癌组织标本,采用免疫组织化学法检测其胃癌癌组织及对应癌旁组织中KLF4和KIF20A表达水平,并结合临床资料进行分析.结果KLF4在胃癌癌组织的表达率明显低于对应癌旁组织(43.48%比78.26%,t=17.524,P<0.01),KLF4表达水平与胃癌组织学分化程度、TNM分期、淋巴结转移明显相关(t=4.261、4.653、6.104,P<0.05);KIF20A在胃癌癌组织的表达率明显高于对应癌旁组织(66.67%比20.29%,t=30.195,P<0.01),KIF20A表达水平与胃癌TNM分期、淋巴结转移明显相关(t=6.048、4.246,P<0.05).结论KLF4在胃癌组织中低表达、KIF20A在胃癌组织中高表达,KLF4和KIF20A可能参与胃癌的发生发展过程.

Objective To explore the expression of Krüppel-like factor 4(KLF4)and kinesin family member 20A(KIF20A)in gastric carcinoma and their clinical value.Methods Gastric carcinoma tissues and adjacent gastric tissues of 69 patients confirmed pathologically at Affiliated Hospital of Guangdong Medical University From May 2014 to February 2019 were collected.The expression of KLF4 and KIF20A proteins in gastric carcinoma tissues and adjacent gastric tissues was detected by immunohistochemistry.Results The positive expression rate of KLF4 in gastric carcinoma tissues was significantly lower than that of adjacent gastric tissues(43.48%vs.78.26%,t=17.524,P<0.01).The positive expression of KLF4 was significantly related with the histology grade,TNM stage and lymph node metastasis of gastric carcinoma(respectively,t=4.261,4.653,6.104,P<0.05).The positive expression rate of KIF20A in gastric carcinoma tissues was significantly higher than that of non-cancerous adjacent gastric tissues(66.67%vs.20.29%,t=30.195,P<0.01),and the positive expression of KIF20A was related with gastric carcinoma to TNM stage and lymph node metastasis(respectively,t=6.048,4.246,P<0.05).Conclusion There was low expression of KLF4 and high expression of KIF20A in gastric carcinoma tissues.Both KLF4 and KIF20A may play important role in the occurrence and development of gastric carcinoma.