程序性细胞死亡因子4和POK红系髓性致癌因子在胰腺癌组织的表达及其临床意义

Expression of programmed cell death 4 and pok erythroid myeloid oncogenic factor in pancreatic cancer and its relationship with clinicopathological characteristics

目的探讨程序性细胞死亡因子4(PDCD4)和POK红系髓性致癌因子(Pokemon)与胰腺癌生物学行为的关系.方法收集经病理确诊的胰腺癌组织标本,采用免疫组织化学方法检测42例胰腺癌组织和21例癌旁组织中PDCD4和Pokemon表达,并进行统计学分析.结果PDCD4蛋白在胰腺癌癌组织中的阳性表达率为54.76%(23/42),明显低于癌旁组织中阳性表达率80.95%(17/21),差异有统计学意义(x^2=4.143,P<0.05),Pokemon蛋白在胰腺癌癌组织中的阳性表达率为57.14%(24/42),明显高于癌旁组织中阳性表达率14.29%(3/21),两者差异有统计学意义(x^2=10.500,P<0.01);PDCD4蛋白表达水平与胰腺癌肿瘤大小、TNM分期、淋巴结转移明显相关(x2=5.999、5.015、6.313,P<0.05),Pokemon表达水平与胰腺癌TNM分期、淋巴结转移明显相关(x2=5.839、4.582,P<0.05).结论联合检测PDCD4和Pokemon有助于评估胰腺癌的侵袭、转移.

Objective To explore the relationship and the biological behaviour of pancreatic cancer between the expression of programmed cell death 4(PDCD4)and pok erythroid myeloid oncogenic factor(Pokemon).Methods Pancreatic cancer tissues pathologically confirmed From January 2012 to April 2019 on Affiliated hospital of guangdong medical university were collected,Immunohistochemical method were used to assess the expression of PDCD4 and Pokemon in 42 cases of pancreatic cancer tissues and 21 cases of non-cancerous adjacent pancreatic tissues.Results The positive rate of PDCD4 protein expression in colorectal carcinoma tissues 54.76%(23/42)was significantly lower than that in non-cancerous adjacent colorectal tissues 80.95%(17/21)(χ^2=4.143,P<0.05),the positive rate of Pokemon protein expression in colorectal carcinoma tissues 57.14%(24/42)was significantly higher than that in non-cancerous adjacent colorectal tissues 14.29%(3/21)(χ^2=10.500,P<0.01);The expressions of PDCD4 protein were related with pancreatic cancer to tumor size,TNM stage,lymph node metastasis(Respectively,χ^2=5.999,χ^2=5.015,6.313,P<0.05),the expressions of Pokemon protein were related with pancreatic cancer to TNM stage,lymph node metastasis(Respectively,χ2=5.839,4.582,P<0.05).Conclusion Combined detection of PDCD4 and Pokemon to judge the invasion and metastasis of pancreatic cancer may have guiding significance.