摘要
CD36又称脂肪酸转运体(FAT),是一种单链跨膜糖蛋白,属于B族清道夫受体,可识别多种配体,并参与多种正常和病理过程.近年来的研究结果表明CD36可能通过调节血管生成、上皮-间充质转化、肿瘤微泡外溢、脂代谢重构等环节在肿瘤侵袭转移中发挥重要作用.本文拟对CD36的结构与正常功能以及CD36在肿瘤侵袭转移中的研究作一综述.
CD36,also known as Fatty Acid Translocase(FAT),is a single chain transmembrane glycoprotein,belonging to the B group scavenger receptors,can identify a variety of ligands,and participate in a variety of normal and pathological processes.Recent studies suggest that CD36 may play an important role in tumor metastasis by regulating angiogenesis,lipid metabolism remodeling,epithelial mesenchymal transition and microvesicle extravasation.The structure and normal function of CD36 and the role of CD36 in tumor metastasis are reviewed.
作者
张帆
程树群
Zhang Fan;Cheng Shuqun(Department of Hepatobiliary Surgery,the Third Affiliated Hospital of Soochow University,Changzhou 213000,China;Department of Hepatic Surgery VI,the Eestern Hepatobiliary Surgery Hospital,Shanghai 200438,China)
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2019年第9期1708-1710,共3页
Chinese Journal of Experimental Surgery
关键词
脂肪酸转运体
肿瘤
侵袭
转移
Fatty acid translocase(FAT/CD36)
Tumor
Invasion
Metastasis
