TANK结合酶1小分子抑制剂的研究进展

Recent Advances in Research on Small-molecule TBK1 Inhibitors

TANK结合酶1(TBK1)属于丝氨酸/苏氨酸蛋白,在肿瘤、免疫、自噬等发生发展过程中发挥关键作用。TBK1激酶成为肿瘤免疫的潜在治疗靶标,但其介导的分子作用机制尚未完全明确。选择性TBK1小分子抑制剂的发现既能够为TBK1蛋白生物学功能探究提供探针工具,同时也为肿瘤免疫治疗提供药物候选化合物。综述近年来TBK1在肿瘤免疫中的作用机制以及TBK1小分子抑制剂的研究进展。

TANK binding kinase 1(TBK1), a crucial serine/threonine kinase, plays a key role in the development of tumors, immunity and autophagy. Though it has gradually become a potential target for cancer immunotherapy, its mechanism has not been fully clarified. The discovery of selective small-molecule inhibitors of TBK1 provides not only essential probe tools for exploring the biological functions of TBK1, but also drug candidates for the treatment. This paper reviews the recent advances in the research on the mechanisms of TBK1 in tumor immunity and small-molecule inhibitors against TBK1.