子宫动脉灌注化疗加栓塞术治疗宫颈癌的临床效果

Clinical effect of uterine artery infusion chemotherapy plus embolization on cervical cancer

目的观察子宫动脉灌注化疗加栓塞术治疗宫颈癌的临床效果.方法选取2017年3月至2019年3月河南省直第三人民医院收治的宫颈癌患者66例,根据随机原则分为常规组及观察组,每组33例.观察组行子宫动脉介入灌注及栓塞术治疗,常规组行常规静脉全身化疗,于化疗结束后2~4周对化疗情况进行评价,比较两组治疗效果、胃肠道反应、阴道流血缓解、术后病理情况.结果观察组治疗有效率为75.76%(25/33)高于常规组的63.64%(21/33),差异有统计学意义(χ^2=9.984,P=0.015).观察组胃肠道反应与常规组比较,差异未见统计学意义(P>0.05).观察组患者阴道流血缓解率高于对照组(χ^2=9.985,P=0.025).观察组患者组织学痊愈率高于常规组(P<0.05),但两组复发高危因素比较差异未见统计学意义(P>0.05).结论子宫动脉灌注化疗加栓塞术治疗宫颈癌,能有效提升治疗效果,提高组织学痊愈率,缓解阴道出血症状,且对胃肠道反应及宫颈癌复发未见明显影响.

Objective To investigate the clinical effects of uterine artery infusion chemotherapy plus embolization for cervical cancer. Methods Sixty-six patients who underwent cervical cancer treatment from March 2017 to March 2019 were selected. The patients were divided into the conventional group and the observation group randomly, with 33 cases in each group. The observation group underwent uterine artery perfusion and embolization. The routine group received routine intravenous systemic chemotherapy.. The therapeutic effects, gastrointestinal reactions, vaginal bleeding, and postoperative pathological results were compared between the two groups 2 to 4 weeks after the end of chemotherapy. Results The effective rate was 75. 76%(25/33) in the observation group and 63. 64%(21/33) in the conventional group, and the difference was statistically significant (χ^2 =9. 984, P=0. 015). There was no significant difference in the gastrointestinal response between the observation group and the conventional group ( P>0. 05 ). The vaginal bleeding remission rate was higher in the observation group than that in the control group (χ^2 =9. 985 , P=0. 025 ). The histological recovery rate of the observation group was higher than that of the conventional group ( P<0. 05 ), but there was no significant difference in the risk factors of recurrence between the two groups ( P >0. 05 ). Conclusions Uterine arterial infusion chemotherapy plus embolization for cervical cancer can effectively improve the therapeutic effect and histological recovery rate, relieve the symptoms of vaginal bleeding, without significant effects on gastrointestinal reactions and recurrence of cervical carcer.