摘要
合成并观察带正电荷的酞菁光敏剂(ZnPc(α-MPz)2)的体内外抗乳腺癌光动力作用疗效.体外细胞实验结果表明,该光敏剂对人源乳腺癌细胞(MCF-7)具有良好的抗肿瘤活性,而对正常的人胚肺成纤维细胞(HELF)没有明显影响.在体内的动物实验结果也证实,该光敏剂比对照药(ZnPc-OH)具有更强的抗肿瘤作用以及肿瘤成像.相关组织切片结果也显示:光敏剂ZnPc(α-MPz)2对小鼠肿瘤组织有明显破坏作用.综合上述实验结果,提示光敏剂ZnPc(α-MPz)2在肿瘤部位蓄积,增强其肿瘤成像并发挥其靶向抗肿瘤作用.
We investigated the anti-breast cancer effects of phthalocyanine(ZnPc(α-MPz)2) both in vivo and in vitro.ZnPc(α-MPz)2 showed excellent antitumor activity against human breast cancer cells(MCF-7) with no toxicity to human embryonic lung fibroblasts(HELF) in vitro.Comparing with ZnPc-OH,ZnPc(α-MPz)2 present its high-efficient anti-tumor effects in tumor-bearing mice along with good-quality tumor imaging.Histopathological examinations on these mice further confirmed that obvious change was observed in tumors of mice after they received ZnPc(α-MPz)2.These results indicated that ZnPc(α-MPz)2 is more likely to accumulate in tumor sites which probably due to its positive charges and thus play the anti-tumor effects more efficiently.
作者
戴涛
胡萍
杨永帅
刘见永
潘小宏
陈卓
DAI Tao;HU Ping;YANG Yong-shuai;LIU Jian-yong;PAN Xiao-hong;CHEN Zhuo(College of Life Sciences,Fujian Agriculture and Forestry University,Fuzhou 350002,China;State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou350002,China;College of Chemistry, Fuzhou University, Fuzhou 35QU6,China)
出处
《福建师范大学学报（自然科学版）》
CAS
北大核心
2019年第5期67-73,共7页
Journal of Fujian Normal University：Natural Science Edition
基金
国家自然科学基金面上项目(81572944、21471033)
福建省引进高层次创业创新人才项目(闽委人才[2018]8-1)
福建省自然科学基金资助项目(2015J01419、2018J05031)
关键词
酞菁
光敏剂
乳腺癌
肿瘤成像
组织病理切片
phthalocyanine
photosensitizer
breast cancer
tumor imaging
histopathological examination
