摘要
脑深部电刺激(deep brain stimulation,DBS)不仅可以显著改善帕金森病的运动症状,而且可以有效地减少左旋多巴所致的运动并发症。在过去的20余年里,DBS已经成为中晚期帕金森病的最有效的治疗方案之一。术前严格筛选合适的患者,术中精准植入电极,以及术后个体化程控和药物调整是DBS最佳疗效和最小副反应的保证。方向性脑深部电刺激和可视化程控模式等新技术将可能进一步优化DBS的疗效。
Deep brain stimulation (DBS) can not only significantly improve the motor symptoms of Parkinson's disease (PD), but also effectively reduce the refractory motor complications caused by levodopa. During the past 20 years, DBS has turned into one of the most successful treatment strategies in advanced stages of the PD. Careful patient selection, accurate electrode implantation during surgery, and individualized programming and drug adjustment are the guarantees for optimal efficacy and minimal side effects of DBS. New technologies such as directional deep brain stimulation and visual programming modes will further optimize the efficacy of DBS.
作者
冼文彪
陈玲
XLAN Wen-biao;CH EN Ling(Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2019年第9期778-782,共5页
Chinese Journal of Practical Internal Medicine
基金
广东省科技重点领域研发计划(2018B030337001)
科技部国家重点研发计划(2016YFC1306500,2016YFC1306504)
广东省重大神经疾病诊治研究重点实验室(2017B030314103)
广东省自然科学基金项目(2015A030313164)
华南神经疾病早期干预及功能修复研究国际合作基地(项目编号2015B050501003)
广东省神经系统重大疾病诊治工程技术研究中心
广东省神经系统重大疾病诊治转化医学创新平台
关键词
脑深部电刺激
帕金森病
刺激参数
程控
deep brain stimulation
Parkinson’s disease
stimulation parameters
programming
