非酒精性脂肪性肝病与少肌症关系的研究进展

Research advances in the relationship between nonalcoholic fatty fiver disease and sarcopenia

非酒精性脂肪性肝病是常见的慢性肝脏疾病之一,可从非酒精性单纯性脂肪肝逐渐进展至肝炎、肝硬化甚至肝衰竭及肝细胞癌。少肌症是一种以骨骼肌量和功能下降为特点、伴随代谢功能紊乱的进展性疾病。近年的研究结果显示少肌症与非酒精性脂肪性肝病的发生和发展具有相关性,两者之间既有共同的发病基础,又可能相互促进,互为危险因素。现对近年来这方面的研究进展进行综述,以便临床上进一步认识两者的发病机制和内在联系,寻找合适的干预措施。

Nonalcoholic fatty liver disease (NAFLD) is one of the common causes for chronic liver diseases, which progress gradually from nonalcoholic type simple fatty liver disease to hepatitis, cirrhosis and even liver failure and hepatocellular carcinoma. Sarcopenia is a progressive disease characterized by reduced skeletal muscle mass and function in association to metabolic dysfunctions. Recent studies have shown that the occurrence and development of NAFLD and sarcopenia are related, and there is a common base for the pathogenesis between the two, which may promote each other for mutual risk factors. This article reviews the current research progress of this field in order to clinically further understand the pathogenesis and intrinsic links between the two to look for appropriate interventions.