摘要
目的研究康柏西普玻璃体内注射联合532 nm激光全视网膜光凝在糖尿病视网膜病变(DR)患者中的应用效果。方法选取2016年1月至2018年6月收治的DR患者117例,按治疗方法不同分为实验组(59例)和对照组(58例)。对照组予以532 nm激光全视网膜光凝治疗,实验组予以康柏西普玻璃体内注射联合532 nm激光全视网膜光凝治疗。对比两组临床疗效,并发症,治疗前及治疗后最佳矫正视力(BCVA)、视网膜厚度、血清血管内皮生长因子(VEGF)、成纤维细胞生长因子(bFGF)、氧化应激反应[血清丙二醛(MDA)、活性氧(ROS)、脂质过氧化氢(LHP)水平]。结果实验组总有效率为93.22%,较对照组的79.31%高(P<0.05);治疗后1个月、3个月两组BCVA及视网膜厚度显著改善,且实验组优于对照组(P<0.05);治疗后1个月两组血清VEGF、bFGF水平均显著改善,且实验组低于对照组(P<0.05);治疗后1个月实验组血清MDA、ROS、LHP水平低于对照组(P<0.05);实验组并发症发生率6.78%(4/59)与对照组3.45%(2/58)对比,差异无统计学意义(P>0.05)。结论在532 nm激光全视网膜光凝基础上加用康柏西普玻璃体内注射可进一步降低血清VEGF、bFGF水平,缓解氧化应激,提高DR疗效,改善视功能,且安全性高。
Objective To study the effect of intravitreal injection of Compaqip combined with 532 nm laser retinal photocoagulation in patients with diabetic retinopathy(DR).Methods A total of 117 patients with DR from January 2016 to June 2018 were selected and divided into experimental group(n=59) and control group(n=58) according to different treatment methods.The 532 nm laser retinal photocoagulation was conducted in control group,and the intravitreal injection of Compaqip was performed in experimental group based on 532 nm laser retinal photocoagulation.The clinical efficacy,complications,best corrected visual acuity(BCVA) before and after treatment,retinal thickness,levels of serum vascular endothelial growth factor(VEGF) and fibroblast growth factor(bFGF),oxidative stress response [serum levels of malondialdehyde(MDA),reactive oxygen species(ROS),lipid hydroperoxides(LHP)] were compared between two groups.Results The total effective rate in experimental group was significantly higher than that in control group(93.22% vs 79.31%,P<0.05);BCVA and retinal thickness were significantly improved at 1-,3-month postoperatively in both groups and were better in experimental group than those in control group(all P<0.05).One month after treatment,the levels of serum VEGF and bFGF significantly decreased in two groups and were statistically lower in experimental group than those in control group(all P<0.05);the levels of serum MDA,ROS and LHP in experimental group were significantly lower than those in control group(all P<0.05).There was no statistical difference in the incidence of complications between experimental group and control group( 6.78% vs 3.45%,P>0.05).Conclusion In the treatment of diabetic retinopathy,intravitreal injection of Compaqip combined with 532 nm laser retinal photocoagulation can further reduce serum VEGF and bFGF levels,alleviate oxidative stress,improve the curative efficacy of DR and visual function with high safety.
作者
康建芳
孙昊
冯军
KANG Jian-fang;SUN Hao;FENG Jun(Department of Ophthalmology,The Affiliated Huai′an Hospital of Xuzhou Medical Hospital,The Second People′s Hospital of Huai′an,Huai'an,Jiangsu 223002,China)
出处
《中国临床研究》
CAS
2019年第9期1189-1192,共4页
Chinese Journal of Clinical Research
基金
江苏省青年医学人才项目(QNRC2016905)~~