药物涂层球囊在经皮冠状动脉介入术中的临床应用及研究现状

Clinical application and research status of drug-coated balloon in percutaneous coronary intervention

我国经皮冠状动脉介入术增长率逐年增高,早期靶血管缺血、再狭窄和再闭塞等问题成为介入治疗领域的难点和热点。多项临床研究表明,无论是裸金属支架还是药物洗脱支架,置入后都可能引起一系列的不良反应,并且术后需要较长时间的双联抗血小板治疗。近些年来,随着对药物涂层球囊的深入研究,其应用范围也在不断的扩大,尤其是在治疗再狭窄、小血管分叉病变、弥漫性疾病、慢性完全性闭塞病变和钙化复合病变等方面表现出了相当的优越性。本文对药物涂层球囊的作用机制及其相关临床研究进展综述如下。

The growth rate of percutaneous coronary intervention is increasing in China. Early target vascular ischemia,restenosis and re-occlusion are difficulties and hot spots in the field of interventional therapy.Clinical studies have shown that both bare metal stents and drug-eluting stents may cause a series of adverse reactions and long-term dual anti-platelet therapy is needed after implantation. In recent years,with the in-depth study of drug-coated balloon,its indications is expanding,especially showing great advantages in the treatment of restenosis,small vessel bifurcation lesions,diffuse lesions,chronic complete occlusion lesions and calcification.This article reviewed the mechanism and clinical research progress of drug-coated balloon.