血必净注射液联合磷酸肌酸钠对感染性心内膜炎患儿心肌功能的影响

Effect of Xuebijing injection combined with phosphocreatine on myocardial function of children with infectious endocarditis

目的:观察血必净注射液联合磷酸肌酸钠对感染性心内膜炎(IE)患儿心肌功能的影响。方法:选择某院收治的IE患儿94例,根据随机数表法分为2组,每组各47例。2组患儿均接受常规治疗,对照组采用磷酸肌酸钠治疗,观察组采取血必净注射液联合磷酸肌酸钠治疗。对比分析2组患儿的临床疗效、炎性因子指标[白细胞计数、C反应蛋白(CRP)、白细胞介素-6(IL-6)]、心肌学指标[磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)、天冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)]和心肌钙蛋白(cTnI)情况。结果:观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后观察组白细胞计数、CRP、IL-6、CK、CK-MB、AST、LDH和cTnI指标均低于对照组,2组比较差异有统计学意义(P<0.05)。结论:采用血必净注射液联合磷酸肌酸钠治疗IE患儿,可有效改善患儿心肌功能,降低炎性因子水平,临床疗效显著。

Objective:To observe the effect of Xuebijing injection combined with phosphocreatine on myocardial function of children with infectious endocarditis(IE).Methods:94 children with IE were randomly divided into two groups,with 47 cases in each group.The control group was treated with phosphocreatine,while the observation group was treated with Xuebijing injection combined with phosphocreatine.The clinical efficacy,inflammatory factors[white blood cell count,C-reactive protein(CRP),interleukin-6(IL-6)],myocardial indexes[creatine phosphokinase(CK),creatine kinase isoenzymes(CK-MB),aspartate transaminase(AST),lactic dehydrogenase(LDH)],and cardiac troponin(cTnI)in the two groups were compared.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the white blood cell count,CRP,IL-6,CK,CK-MB,AST,LDH and cTnI in the observation group were lower than those in the control group(P<0.05).Conclusion:Xuebijing injection combined with phosphocreatine in treatment of children with IE can improve myocardial function and decrease the levels of inflammatory factors,which has significant clinical efficacy.