纳布啡对老年胃癌根治术患者麻醉应激反应及苏醒期躁动的影响

Effect of nalbuphine on anaesthetic stress response and emergence agitation in senile patients with radical operation for gastric cancer

目的:探讨纳布啡对老年胃癌根治术患者麻醉应激反应及苏醒期躁动的影响。方法:选取某院行胃癌根治术的72例老年患者,利用随机数字表法分为2组,每组各36例。手术结束前30min,观察组静脉注射0.2mg/kg纳布啡,对照组静脉注射等量生理盐水,对比2组患者苏醒时间指标、应激反应及苏醒期躁动发生情况。结果:2组患者睁眼时间、自主呼吸恢复时间比较,差异无统计学意义(P>0.05);T1、T2时段,观察组血糖、血清皮质醇及肾上腺素水平均较对照组低,差异有统计学意义(P<0.05);观察组苏醒期躁动发生率较对照组低,且躁动程度较对照组轻,差异有统计学意义(P<0.05)。结论:纳布啡用于老年胃癌根治术效果满意,可有效减轻患者麻醉应激反应,降低苏醒期躁动发生率,值得临床推广。

Objective:To investigate the effect of nalbuphine on anaesthetic stress response and emergence agitation in senile patients with radical operation for gastric cancer.Methods:72 senile patients with radical operation for gastric cancer were randomly divided into two groups,with 36 cases in each group.30min before the end of surgery,the observation group was given intravenous injection of 0.2mg/kg nalbuphine,and the control group was given intravenous injection of same dose of saline.The indexes of awakening time,stress response and emergence agitation were compared between the two groups.Results:There was no statistical difference in the time of opening eye and the recovery time of autonomous respiration between the two groups(P>0.05).The levels of blood glucose,serum cortisol and epinephrine in the observation group at T1 and T2 were lower than those in the control group(P<0.05).The incidence of emergence agitation in the observation group was lower than that in the control group,and the degree of agitation in the observation group was slighter than that in the control group(P<0.05).Conclusion:Nalbuphine in senile patients with radical operation for gastric cancer can reduce anaesthetic stress response and decrease the incidence of emergence agitation,which is worthy of clinical promotion.