中西医结合治疗甲状腺功能亢进性肝损害临床观察

Hyperthyroidism;Liver damage;Integrated traditional Chinese and Western medicine;Control treatment and observation

目的:观察化肝煎加味联合西药治疗甲亢性肝损害肝郁火旺型的临床疗效。方法:80例随机分为对照组与观察组各40例。对照组予以甲巯咪唑片配合护肝治疗,观察组予以甲巯咪唑联合化肝煎加味治疗,比较治疗前后两组甲状腺功能、肝功能、中医证候评分,比较治疗期间不良反应情况。结果:治疗后两组FT3、FT4均比治疗前降低,TSH升高(P<0.05),治疗后两组ALT、AST、γ-GT、ALP、TBI指标比治疗前降低(P<0.05),且观察组降低更明显(P<0.05)。结论:化肝煎加味联合小剂量甲巯咪唑片治疗甲亢性肝损害,与大剂量甲巯咪唑片配合降酶护肝药效果相当,但改善不适症状有明显优势。

Objective:To observe the clinical efficacy of Huagan Decoction combined with western medicine in the treatment of hyperthyroid liver damage with liver qi stagnation and excessive fire type. Method: 80 patients were evenly divided into control group and observation group in random. The control group were treated with methimazole tablets combined with liver protection. The observation group was treated with methimazole combined with Huagan Decoction. The thyroid function, liver function and TCM syndrome scores were compared before and after treatment, and the adverse reactions during treatment were compared. Result: After treatment, FT3 and FT4 were lower than those before treatment and TSH was increased(P<0.05). After treatment, the ALT, AST,γ-GT, ALP and TBI indexes were lower than those before treatment(P<0.05). The decrease in the observation group was more obvious(P<0.05). Conclusion: Modified Huagan Decoction combined with low-dose methimazole tablets have similar therapeutic effect to high-dose methimazole tablets combined with enzyme-lowering liver-protecting drugs in the treatment of hyperthyroid liver damage, but which has obvious advantage in improving symptoms of discomfort.