干细胞因子在女性生殖发育及相关生殖疾病中的研究进展

Research progress of stem cell factor in female reproductive development and related diseases

干细胞因子(stem cell factor,SCF)又称肥大细胞生长因子或酪氨酸激酶受体(c-Kit)配体,属于白细胞介素超家族。SCF是一种可与c-Kit结合的酸性糖蛋白类上皮细胞生长因子。SCF在女性卵巢中主要由颗粒细胞合成及分泌,其主要作用是通过与c-Kit结合,在调节颗粒细胞、卵泡膜细胞、间质细胞、子宫内膜上皮细胞、胚胎滋养细胞增殖分化以及卵泡募集、生长发育,卵子成熟等过程中发挥重要作用。本文主要阐述SCF在女性生殖发育中的作用,及其与相关生殖疾病的联系,以期更好地指导相关临床工作。

Stem cell factor (SCF), also called as mast cell growth factor or tyrosine kinase receptor (c-Kit) ligand, is an acidic glycoprotein epithelial growth factor in interleukin superfamily that can bind to c-Kit. It is mainly synthesized and secreted by granulosa cells in female ovaries. SCF plays important roles in the regulation of the proliferation and differentiation of granulosa cells, follicular membrane cells, stromal cells and endometrial epithelial cells as well as follicular recruitment, growth, development and maturation by binding to c-Kit. Meanwhile, it also participated in some certain diseases in female reproductive system. In this paper, it describes the role of SCF in female reproductive development and its relationship with related reproductive diseases in order to guide the clinical work better.