长链非编码RNA与鼻咽癌发生发展的研究进展

Research progress on the correlation between long non-coding RNA and nasopharyngeal carcinoma

长链非编码RNA(long non-coding RNA,lncRNA),即长度大于200nt的RNA分子,被发现在转录及转录后水平参与调控基因表达,参与遗传修饰的调控,部分lncRNA在鼻咽癌的发生发展中起到一定调控作用,并可能成为鼻咽癌预后的标志物。本文就肿瘤相关lncRNA在鼻咽癌中的作用进行简单综述。

Long non-coding RNA(lncRNA),namely RNA molecules with length greater than 200 nt,is found to be involved in the regulation of gene expression and the regulation of genetic modification at the level of transcription and post-transcription.Part of lncRNA plays a certain regulatory role in the occurrence and development of nasopharyngeal cancer and may become a marker for the prognosis of nasopharyngeal cancer.This paper briefly reviews the role of tumor-associated lncRNA in nasopharyngeal carcinoma.