宫颈癌患者血清胰岛素样生长因子1、基质金属蛋白酶9的水平及临床意义

Serum levels of insulin-like growth factor 1 and matrix metalloproteinase 9 in patients with cervical cancer and their clinical significance

目的探讨宫颈癌患者血清胰岛素样生长因子1(IGF1)及基质金属蛋白酶9(MMP9)的水平及临床意义。方法选取206例宫颈癌患者为宫颈癌组,100例健康体检女性为对照组,比较两组受试者的血清IGF1、MMP9水平,并对血清IGF1、MMP-1水平与宫颈癌患者年龄、临床分期、分化程度、浸润程度及淋巴结转移的相关性进行分析。结果宫颈癌组的血清IGF1、MMP9水平均明显高于对照组(P﹤0.01)。不同临床分期、分化程度、浸润深度、淋巴结转移情况宫颈癌患者的血清IGF1、MMP9水平比较,差异均有统计学意义(P﹤0.01);不同年龄宫颈癌患者的血清MMP9水平比较,差异有统计学意义(P﹤0.01)。血清IGF1水平与宫颈癌患者的临床分期、分化程度、浸润深度、淋巴结转移情况及MMP9水平呈正相关(P﹤0.05);血清MMP9水平与宫颈癌患者的浸润深度、淋巴结转移情况及IGF1水平均呈正相关(P﹤0.05)。结论宫颈癌患者血清IGF1、MMP9水平均明显升高,且与患者的临床分期、分化程度、浸润深度及淋巴结转移情况有关。

Objective To study the serum levels of insulin-like growth factor 1(IGF1)and matrix metalloproteinase 9(MMP9)in patients with cervical cancer and their clinical significance.Method A total of 206 patients with cervical cancer were included in the analysis as cervical cancer group,meanwhile another 100 healthy women were enrolled as control group.The levels of serum IGF1 and MMP9 were detected and compared between the two groups,besides,the correlations among serum levels of IGF1 and MMP9 with age,clinical stage,degree of differentiation,depth of invasion and lymph node metastasis were analyzed across patients with cervical cancer.Result Compared with control group,the serum IGF1 and MMP9 levels in cervical cancer group were significantly increased,with statistically significant differences observed(P<0.01).There were significant differences in serum levels of IGF1 and MMP9 in cervical cancer patients with different clinical stages,degree of differentiation,depth of invasion and lymph node metastasis(P<0.01);and the serum level of MMP9 was evidently associated with patients’age(P<0.01).The level of serum IGF1 was positively correlated with clinical stage,degree of differentiation,depth of invasion,lymph node metastasis and MMP9 level of cervical cancer patients(P<0.05),and the level of serum MMP9 was positively correlated with the depth of invasion,lymph node metastasis and IGF1 level of cervical cancer patients(P<0.05).Conclusion The expression levels of serum IGF1 and MMP9 in patients with cervical cancer are significantly increased,and are correlated with clinical stage,degree of invasion,depth of invasion and lymph node metastasis.