2010-2017年天津市滨海新区健康人群人肠道病毒71型血清中和抗体动态变化研究

Dynamic changes in EV-A71 neutralizing antibody inhealthy people living in Binhai New Area of Tianjin,China, from 2010 to 2017

目的:了解天津市滨海新区健康人群人肠道病毒71型(EV-A71)中和抗体动态变化,为手足口病防控方案提供依据。方法:采集2010-2017年天津市滨海新区健康人的血清学标本368份,进行EV-A71中和抗体测定,并对监测结果进行统计学分析。结果:EV-A71中和抗体阳性率为79.35%;不同年份间的抗体阳性率差异有统计学意义(χ^2=6.695,P=0.01),呈周期性变化;不同年龄组人群的抗体阳性率差异有统计学意义(χ^2=46.531,P<0.01),5岁及以下年龄组抗体阳性率最低为59.26%;5岁以下各年龄组抗体阳性率无统计学差异(χ^2=1.481,P=0.830);不同性别间抗体阳性率差异无统计学意义(χ^2=3.480,P=0.062);以健康人群EV-A71中和抗体阳性率作为应变量,对健康人群的卫生习惯及环境进行Logistic回归分析,发现与没去过医院的相比,半年内去过医院患病风险更大(OR=2.291,95%CI:1.488~4.946)。结论:天津市滨海新区人群EV-A71中和抗体水平较高,易感人群为5岁及以下年龄组儿童,继续加强和完善EV-A71流行监测系统是防控手足口病的重要环节。

Objective: To understand the dynamic changes of human enterovirus 71(EV-A71) and antibodies in healthy population of BinhaiNew Area of Tianjin, and provide the basis for the prevention and control of hand-foot-mouth disease(HFMD). Methods: A total of 368 serological specimens of healthy people in Binhai New Area of Tianjin were collected from 2010 to 2017, the determination of EV-A71 neutralization antibody was carried out, and the monitoring results were analyzed statistically. Results: The positive rate of EV-A71 neutralizing antibody was 79.35%;The positive rate of antibody in different years was statistically significant(χ^2=6.695,P=0.01)and showed periodic change;The positive rate of antibody in different age groups was statistically significant(χ^2=46.531,P<0.01), the positive rate of antibody in the age group 5 and below was 59.26%. There was no statistical difference in the positive rates of antibody between all age groups under 5 years old(χ^2=1.481,P=0.830);There was no significant difference in the positive rates between different genders(χ^2=3.480,P=0.062);The positive rate of EV-A71 antibody in healthy population was used as the dependent variable, logistic regression analysis was carried out on the health habits and environment of healthy population, and it was found that compared with those who have not been to the hospital, it was more risky for patients to go to the hospital within half a year(OR=2.291,95%CI:1.488~4.946). Conclusion:In Binhai New Area of Tianjin, the population EV-A71 antibody level is higher. V vulnerable groups are children aged 5 and under, and to strengthen and improve the EV-A71 epidemic monitoring system is an important part in the prevention and control of HFMD.