丙种球蛋白对重症肌无力患者调节性 T细胞及TNF-α、IL-2水平的影响

Effect of gamma globulin on regulatory T cells,TNF-α and IL-2 levels in patients with myasthenia gravis

目的 分析丙种球蛋白对重症肌无力患者调节性T细胞及TNF-α、IL-2水平的影响。方法 选取2017年5月至2018年9月收治的98例重症肌无力患者为研究对象,按照随机数字表分为两组,各49例。对照组给予常规治疗,在此基础上观察组给予丙种球蛋白治疗。观察两组疗效、调节性T细胞(CD4+OX40+T、CD4+CD25+T)及炎症因子(TNF-α、IL-2)水平。结果 对照组治疗总有效率低于观察组,差异有统计学意义(P<0.05);治疗后两组CD4+OX40+T、CD4+CD25+T细胞、IL-2、TNF-α均低于治疗前,且观察组降低更加显著,差异有统计学意义(P<0.001)。结论 丙种球蛋白治疗可有效降低重症肌无力患者T细胞及炎症因子水平,促进机体免疫功能的改善,提高临床效果。

Objective To analyze the effects of gamma globulin on regulatory T cells,TNF-α and IL-2 levels in patients with myasthenia gravis. Methods 98 patients with myasthenia gravis admitted to our hospital from May 2017 to September 2018 were enrolled in the study.They were divided into two groups according to random number table,with 49 cases in each group.Control group were given conventional treatment,and on this basis,observation group were treated with gamma globulin.And then,the therapeutic effects,regulatory T cells(CD4 +OX40 +T,CD4 +CD25 +T) and the levels of inflammatory factors(TNF-α and IL-2) were observed in the two groups. Results The total effective rate of the control group was lower than that of the observation group,and difference was statistically significant( P <0.05).After treatment,the CD4 +OX40 +T and CD4 +CD25 +T cells,IL-2 and TNF-α levels in both groups were lower than those before treatment,the decrease in the observation group was more significant,and difference was statistically significant( P <0.001). Conclusion Gamma globulin can effectively reduce the levels of T cells and inflammatory factors in patients with myasthenia gravis,promote the improvement of immune function and improve the clinical effect.