阿尔茨海默症脑组织基质辅助激光解吸电离质谱成像分析研究新进展

Research Progress of Matrix Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Alzheimer’s Disease Brain

阿尔兹海默症(Alzheimer’s disease,AD)是影响全球数百万人并与年龄有关的神经退行性疾病,但确切病因仍不清楚。基质辅助激光解吸电离质谱成像(MALDI MSI)分析技术不仅可进行物质鉴定,而且可对被分析物进行空间分布成像,近年来广泛应用于AD脑组织中淀粉样蛋白和脂质的分布研究,以探索该疾病的机理。本文介绍了基质辅助激光解吸电离质谱成像(MALDI MSI)的原理、方法学以及在AD疾病机制方面的相关研究进展,并对其发展前景进行了展望。

Alzheimer’s disease(AD)is an age-related neurological disorder,affecting millions of people around the world,but the exact cause of the disease remains unclear.Matrix assisted laser desorption ionization mass spectrometry imaging(MALDI MSI)analysis technology not only enables material identification,but also spatially images the analytes.In recent years,MALDI MSI technique has been widely applied to the study of the distribution ofβ-amyloid(Aβ)and lipid in AD brain tissue.The principle,methodology of MALDI MSI and related research progress of the mechanism of AD treatment were reviewed in this paper,and the prospects for its development were also anticipated.