GnRH激动剂黄体期长方案的优势与不足

Advantages and disadvantages of GnRH agonist long protocol in luteal phase

促性腺激素释放激素激动剂(GnRH-a)黄体期长方案是目前国内常用的经典方案,该方案在获卵数、优质胚胎数以及子宫内膜容受性方面具有优势,但该方案仍有一些不足,包括导致卵巢过度刺激综合征(OHSS)的发生率增加、促性腺激素(Gn)用量及用时增加、卵巢囊肿形成以及历时较长、患者生活质量报告下降等。但根据其治疗效果,该方案对多数人群友好,可以获得良好的妊娠结局,仍可作为目前主流的治疗方案进行推广。

GnRH agonist long protocol in luteal phase is a classic protocol commonly used in China at present.The protocol has advantages in the number of oocytes retrieved,the number of high quality embryos,and the endometrial receptivity.However,the short comings of the protocol including increased incidence of ovarian hyperstimulation syndrome(OHSS),more gonadotropin dosage used,the formation of ovarian cyst and longer duration,decreasing life quality of patients,etc.According to the treatment outcomes,this protocol is friendly to most of patients and can achieve a satisfying pregnancy outcome.Thus this protocol is still can be chosen as the first line controlled ovarian stimulation protocol for clinicians.