父代肥胖对精子表观遗传跨代继承的影响

Impact of parental obesity on sperm epigenetic intergenerational inheritance

父代肥胖会导致精子表观遗传修饰的改变,这种异常的表观遗传修饰会传递至后代,对后代健康产生严重影响.本文主要综述了由于父代肥胖所致的DNA甲基化、组蛋白修饰和非编码RNA等表观遗传修饰的异常及其跨代继承的机制,从表观遗传水平阐述父代肥胖对自身和后代健康的影响,可为后代相关疾病的预防和诊断提供参考资料.

Paternal obesity can lead to some defects of epigenetic modification in sperm,which is passed on to the offspring with a serious impact on the health.This article reviews the abnormal epigenetic modifications such as DNA methylation,histone modifications,and non-coding RNAs due to paternal obesity and the mechanism of intergenerational inheritance of paternal obesity,as well as the epigenetic effects from parental obesity on the health of parents and children,providing reference materials for prevention and diagnosis of the related diseases in offspring.