鲍曼不动杆菌对多黏菌素类抗菌药物耐药现状及机制研究进展

Advances in research on the status and mechanism of Acinetobacter baumannii resistance to polymyxins

多黏菌素类抗菌药物是多重耐药鲍曼不动杆菌的最后防线,但随着临床对多黏菌素类药物使用增多,鲍曼不动杆菌对其耐药的报道也陆续出现,相关耐药机制的研究成为热点。本文对近年来国内外鲍曼不动杆菌对多黏菌素类耐药报道以及耐药机制研究进行综述,以期对临床合理应用多黏菌素类抗菌药物、保持其抗菌活性提供参考。

Polymyxin antibiotics are the last line of defense for the multidrug resistant Acinetobacter baumannii.But due to the increasing use of polymyxins in clinical practice,reports of Acinetobacter baumannii resistance have also appeared.Research on drug resistance mechanisms has also become a hot topic.In this paper,the reports on the resistance of polymyxins in Acinetobacter baumannii and the mechanism of drug resistance in recent years are reviewed in order to provide reference for the clinical application of polymyxins and the maintenance of their antibacterial activity.