血尿酸水平与体质量、体质类型的相关性分析

Association of Serum Uric Acid with Body Weight and Type of Constitution

目的分析不同尿酸(uricacid,UA)水平人群的中医体质类型分布状况及相关危险因素。方法选取4844例体检对象,对其年龄、婚姻状况、收入水平、体质量、UA和中医体质类型进行分析。根据UA水平,将受检者分为正常UA组和高UA组,并对有统计学意义的因素进行二分类Logistic回归分析。结果正常UA组与高UA组性别、婚姻状况、体质类型、体质量指数(body mass index,BMI)比较,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,以正常UA组为对照组,气虚质、痰湿质、湿热质者发生高UA的危险度增高[气虚质:OR值为1.097(95%CI为0.885~1.006,P=0.015);痰湿质:OR值为1.311(95%CI为1.007~1.708,P=0.045);湿热质:OR值为1.037(95%CI为0.822~1.307,P=0.022)]。超重、肥胖人群相比正常体质量人群,发生高UA的危险性分别增加145.7%(OR值为2.457,95%CI为2.089~2.889,P=0.000)、317.4%(OR值为4.174,95%CI为3.376~5.162,P=0.000)。结论痰湿质、气虚质、超重和肥胖是高UA血症的危险因素。

Objective To investigate the distribution of traditional Chinese medicine(TCM)constitution types and related risk factors in people with different uric acid(UA)levels.Methods A total of 4 844 subjects who underwent physical examination were enrolled and analyzed in terms of age,marital status,income level,body weight,UA,and TCM constitution type.According to the UA level,the subjects were divided into normal UA group and high UA group,and a binary logistic regression analysis was performed for the factors with statistical significance.Results There were significant differences in sex,marital status,constitution type,and body mass index(BMI)between the normal UA group and the high UA group(P<0.05).The logistic regression analysis showed that with the normal UA group as a control,the subjects with Qi-deficiency constitution,phlegm-dampness constitution,or damp-heat constitution had a higher risk of high UA[Qi-deficiency constitution:odds ratio(OR)=1.097,95%confidence interval(CI):0.885-1.006,P=0.015;phlegm-dampness constitution:OR=1.311,95%CI:1.007-1.708,P=0.045;damp-heat constitution:OR=1.037,95%CI:0.822-1.307,P=0.022].Compared with the population with normal body weight,the populations with overweight and obesity had a risk of high UA increased by 145.7%(OR=2.457,95%CI:2.089-2.889,P=0.000)and 317.4%(OR=4.174,95%CI:3.376-5.162,P=0.000),respectively.Conclusion Phlegm-dampness constitution,Qi-deficiency constitution,overweight,and obesity the risk factors for high UA.