自拟温肾健脾汤治疗脾肾阳虚型亚健康疲劳状态的疗效观察

Observation on Efficacy of Self-Made Wenshenjianpi Decoction in Treatment of Sub-Health Fatigue of Spleen-Kidney-Yang Deficiency

目的:探讨自拟温肾健脾汤治疗脾肾阳虚型亚健康疲劳状态的临床疗效。方法:选取2015年5月至2018年6月秦皇岛市中医医院收治的亚健康状态患者422例,按照随机数字表法分为观察组和对照组,每组211例。对照组患者给予振源胶囊,观察组患者给予自拟温肾健脾汤治疗。比较两组患者的临床疗效、中医证候积分变化情况、疲劳量表-14评分情况和匹兹堡睡眠质量指数(PSQI)。结果:观察组患者的总有效率为91.94%(194/211),明显高于对照组的79.62%(168/211),差异有统计学意义(P<0.05)。1个疗程后,两组患者各项中医证候积分明显低于治疗前,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05);观察组患者躯体疲乏、脑力疲乏和疲乏总分明显低于治疗前和对照组治疗后,差异均有统计学意义(P<0.05)。2个疗程后,观察组患者的PSQI评分为(6.71±1.43)分,明显低于对照组的(9.84±1.67)分,差异有统计学意义(P=0.000)。结论:自拟温肾健脾汤能够有效缓解脾肾阳虚型亚健康疲劳状态患者的临床症状,改善患者亚健康状态,减轻疲劳感,提高睡眠质量。

OBJECTIVE:To probe into the clinical efficacy of self-made Wenshen Jianpi decoction in treatment of sub-health fatigue of spleen-kidney yang deficiency type.METHODS:422 patients in sub-health status who were admitted into Qinhuangdao Hospital of Traditional Chinese Medicine between May 2015 and Jun.2018 were selected.They were divided into observation group and control group by the random number table method,with 211 cases in each group.The control group was treated with Zhenyuan capsules,while the observation group was treated with self-made Wenshen Jianpi decoction.Clinical efficacy,changes of TCM syndrome scores,Fatigue Scale-14 scores and Pittsburgh Sleep Quality Index (PSQI) were compared between the two groups.RESULTS:The total effective rate of observation group was 91.94%(194/211) which was significantly higher than that of the control group 79.62%(168/211),with statistically significant difference ( P <0.05).After 1 course of treatment,the TCM syndrome scores of both groups significantly decreased,and the scores of observation group were significantly lower than those of the control group,with statistically significant differences ( P <0.05).The scores of physical fatigue and mental fatigue and total score of fatigue in the observation group were significantly lower than those in the control group and those before treatment,with statistically significant differences ( P <0.05).After 2 courses of treatment,the PSQI score of observation group was (6.71±1.43) points,which was significantly lower than that of the control group [(9.84±1.67) points],with statistically significant difference ( P =0.000).CONCLUSION:Self-made Wenshen Jianpi decoction can effectively relief clinical symptoms of patients with sub-health fatigue of spleen-kidney yang deficiency type,improve the sub-health status,alleviate feeling of fatigue and improve sleep quality.