同步放化疗对中晚期宫颈癌患者鳞状上皮细胞癌抗原及癌胚抗原水平的影响

Effect of concurrent chemoradiothrapy on squamous cell carcinoma antigen and carcinoembryonic antigen levels in patients with intermediate-advanced cervical cancer

目的分析同步放化疗对中晚期宫颈癌患者鳞状上皮细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)水平的影响。方法选取80例中晚期宫颈癌患者,按照放化疗方式分为对照组与研究组,每组40例。对照组采用序贯放化疗,研究组采用同步放化疗。比较2组患者的SCC-Ag、CEA水平及预后情况。结果研究组总有效率为92.5%,显著高于对照组的75.0%(P<0.05)。与对照组相比,研究组放疗后4周的血小板、粒细胞、白细胞、血红蛋白水平均显著较高(P<0.05)。与对照组相比,研究组放疗后4周的SCC-Ag、CEA水平均显著较低(P<0.05)。结论同步放化疗治疗中晚期宫颈癌患者疗效显著,能减轻毒副反应。

Objective To analyze the effect of concurrent chemoradiothrapy on the squamous cell carcinoma antigen(SCC-Ag)and carcinoembryonic antigen(CEA)levels in patients with intermediate-advanced cervical cancer.Methods Totally 80 patients with intermediate-advanced cervical cancer were selected and divided into control group(n=40)and study group(n=40)according to the ways of chemoradiothrapy.The control group was given sequential chemoradiothrapy,and the study group was given concurrent chemoradiothrapy.The SCC-Ag and CEA levels and prognosis were compared between the two groups.Results The total effective rate was 92.5%in the study group,which was significantly higher than 75.0%in the control group(P<0.05).Compared with the control group,the levels of platelets,granulocytes,white blood cells and hemoglobin in the study group were significantly higher at 4 weeks after radiotherapy(P<0.05).Compared with the control group,the SCC-Agand CEA levels in the study group were significantly lower at 4 weeks after radiotherapy(P<0.05).Conclusion Concurrent chemoradiothrapy is effective in the treatment of intermediate-advanced cervical cancer,which can alleviate toxic and side effects.