清胰承气汤联合杂合式血液净化治疗急性重症胰腺炎患者的疗效分析

Efficiency analysis of Qingyi Chengqi Decoction combined with heterozygous blood purification in treating patients with acute severe pancreatitis

目的分析清胰承气汤联合杂合式血液净化治疗急性重症胰腺炎(ASP)的疗效。方法选取86例ASP患者,随机分为2组各43例。对照组给予杂合式血液净化治疗,观察组给予清胰承气汤联合杂合式血液净化治疗。比较2组总有效率、症状体征改善指标[腹痛消失时间、血淀粉酶(AMS)恢复正常时间、白细胞恢复正常时间]、住院时间、血清AMS、腹内压(IAP)、血清炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平。结果观察组总有效率93.02%,显著高于对照组72.09%(P<0.05)。观察组腹痛消失时间、血AMS恢复正常时间、白细胞恢复正常时间、住院时间均显著短于对照组(P<0.05)。观察组治疗1、3、5d后血清AMS、IAP显著低于对照组(P<0.05)。观察组治疗1、3、5d后血清CRP、TNF-α水平显著低于对照组(P<0.05)。结论清胰承气汤联合杂合式血液净化治疗ASP可有效控制患者机体炎症反应,缓解临床症状,缩短住院时间。

Objective To analyze the efficacy of Qingyi Chengqi Decoction combined with heterozygous blood purification in the treatment of patients with acute severe pancreatitis(ASP).Methods Eighty-six patients with ASP were randomly divided into two groups,with 43 cases in each group.The control group was treated with heterozygous blood purification,while the observation group was given Qingyi Chengqi Decoction combined with heterozygous blood purification.Total effective rate,indicators of symptoms and signs improvement[abdominal pain disappearance time,time of blood amylase(AMS)return to normal,time of white blood cell recovery],hospitalization time,serum AMS level,intra-abdominal pressure(IAP),serum inflammation factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]levels were compared between two groups.Results The total effective rate of the observation group was 93.02%,which was significantly higher than 72.09%of the control group(P<0.05).The disappearance time of abdominal pain,the time of blood AMS return to normal,the time of white blood cell recovery and the hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05).Serum AMS and IAP levels at 1,[CM(31*2]3 and 5 days after treatment in the observation group were significantly lower than those in the control group(P<0.05).The serum CRP and TNF-αlevels at 1,3 and 5 days after treatment in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Qingyi Chengqi Decoction combined with heterozygous blood purification can effectively control the inflammatory reaction of ASP patients,alleviate the clinical symptoms and shorten the hospital stay.