口服避孕药预防宫腔镜子宫内膜息肉切除术后复发的效果观察

Effect of oral administration of contraceptives on prevention of recurrence after hysteroscopic endometrial polypectomy

目的探讨口服避孕药对宫腔镜子宫内膜息肉切除术后复发的预防效果。方法选取240例子宫内膜息肉(EP)患者,采用随机数表法分为对照组和观察组,各120例。对照组患者单纯行宫腔镜子宫内膜息肉切除术治疗,干预组患者手术后口服复方短效避孕药治疗。观察2组术后3、6个月时血红蛋白(Hb)、子宫内膜厚度变化,并比较月经改善和EP复发情况。结果2组术后3、6个月时的血清Hb水平较术前显著升高,子宫内膜厚度显著下降(P<0.05),且观察组术后6个月时Hb水平显著高于对照组,子宫内膜厚度显著低于对照组(P<0.05)。术后6个月时,观察组月经恢复正常率为91.67%,显著高于对照组的78.33%(P<0.05),且观察组EP复发率4.17%,显著低于对照组14.17%(P<0.05)。结论宫腔镜子宫内膜息肉切除术后口服短效避孕药,能提高患者血清Hb水平,抑制子宫内膜过度增生,对改善月经和预防EP复发效果显著。

Objective To investigate the effect of oral administration of contraceptives on prevention of recurrence after hysteroscopic endometrial polypectomy.Methods A total of 240 patients with endometrial polyps(EP)were randomly divided into control group(n=120)and observation group(n=120).The control group was treated with hysteroscopic endometrial polypectomy alone,and the observation group was treated with compound short-acting contraceptives after operation.The changes of hemoglobin(Hb)and endometrial thickness were observed at 3 and 6 months after operation,and menstrual improvement and EP recurrence were compared between the two groups.Results The serum Hb level increased significantly,and the endometrial thickness decreased significantly at 3 and 6 months after operation(P<0.05),and the observation group changes more significantly at 6 months after operation than the control group(P<0.05).The rate of returning to regular menstruation at 6 months after operation in the observation group was higher,and the recurrence rate of EP was lower than that in the control group(91.67%vs.78.33%,4.17%vs.14.17,P<0.05).Conclusion Oral administration of short-acting contraceptives after hysteroscopic endometrial polypectomy can increase the level of serum Hb and inhibit endometrial hyperplasia,and play a positive role in improving menstruation and prevention of EP recurrence.