中药汤剂联合阿立哌唑治疗慢性精神分裂症的疗效观察

Efficacy observation of traditional Chinese medicine decoction combined with aripiprazole in the treatment of chronic schizophrenia

目的探讨中药汤剂联合阿立哌唑治疗慢性精神分裂症的临床疗效。方法将60例慢性精神分裂症患者随机分为联合治疗组(中药汤剂联合阿立哌唑)与单独治疗组(单用阿立哌唑),每组30例。比较2组患者的阳性和阴性综合征量表(PANSS)评分、生活质量、不良反应发生情况、临床疗效。结果2组患者治疗后的精神病理、阳性症状、阴性症状评分及PANSS总分均显著低于治疗前(P<0.05),且联合治疗组患者治疗后的精神病理、阳性症状、阴性症状评分及PANSS总分均显著低于单独治疗组(P<0.05)。2组患者治疗后的症状/副反应、精力/动机、心理/社会评分及精神分裂症患者生活质量量表(SQLS)总分均显著低于治疗前(P<0.05),且联合治疗组患者治疗后的症状/副反应、精力/动机、心理/社会评分及SQLS总分均显著低于单独治疗组(P<0.05)。2组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。联合治疗组患者总有效率96.7%,显著高于单独治疗组80.0%(P<0.05)。结论中药汤剂联合阿立哌唑治疗慢性精神分裂症的临床疗效显著。

Objective To explore the clinical efficacy of traditional Chinese medicine decoction combined with aripiprazole in the treatment of chronic schizophrenia.Methods Sixty patients with chronic schizophrenia were randomly divided into combined treatment group (traditional Chinese medicine decoction combined with aripiprazole) and single treatment group (aripiprazole only),with 30 cases in each group.The score of positive and negative syndrome scale (PANSS),quality of life,incidence of adverse reactions and clinical efficacy were compared between the two groups.Results The scores of psychopathology,positive symptoms,negative symptoms and PANSS in both groups after treatment were significantly lower than those before treatment ( P <0.05),and the scores of items mentioned above in the combined treatment group were significantly lower than those in the single treatment group ( P <0.05).The scores of symptoms/side effects,energy/motivation,psychological/social and total score of Schizophrenia Quality of Life Scale (SQLS) in both groups after treatment were significantly lower than those before treatment ( P <0.05),and the scores of items mentioned above in the combined treatment group were significantly lower than those in the single treatment group ( P <0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups ( P >0.05).The total effective rate of the combined treatment group was 96.7%,which was significantly higher than 80.0% of the single treatment group ( P <0.05).Conclusion Traditional Chinese medicine decoction combined with aripiprazole is effective in the treatment of chronic schizophrenia.