阿替洛尔联合地塞米松对浅表型婴幼儿血管瘤bFGF、PCNA表达水平的影响

Effect of atenolol combined with dexamethasone on expression of bFGF and PCNA in superficial infantile hemangioma

目的探究浅表型婴幼儿血管瘤(IH)患者在使用阿替洛尔联合地塞米松后对碱性成纤维细胞生长因子(bFGF)、增殖细胞核抗原(PCNA)表达水平的影响。方法研究对象为2016年9月~2018年5月收治的80例浅表型IH患者,将其采用随机数字表法分成观察组与对照组,40例观察组采用阿替洛尔联合地塞米松治疗,另40例对照组采用盐酸曲安奈德治疗。观察不同治疗方法对临床疗效、bFGF、PCNA表达水平和肝功能的影响。结果观察组总有效率(95.00%)显著高于对照组(80.00%)(P<0.05);观察组不良反应发生率(7.50%)显著比对照组(25.00%)低(P<0.05);治疗后1周,观察组bFGF和PCNA水平显著比对照组低(P<0.05)。结论将阿替洛尔联合地塞米松应用于浅表型IH患者时,能发挥协同作用,提升治疗效果,降低不良反应,显著降低bFGF和PCNA水平。

Objective To investigate the effect of atenolol combined with dexamethasone on the expression of basic fibroblast growth factor( bFGF) and proliferating cell nuclear antigen( PCNA) in superficial infantile hemangioma. Methods 80 patients with superficial IH admitted to our hospital from September 2016 to May 2018 were divided into observation group andcontrol group by random number table. 40 patients in observation group were treated with atenolol combined with dexamethasone,and 40 patients in control group were treated with triamcinolone hydrochloride to explore the effect of different treatments on clinical efficacy,the expression of bFGF and PCNA expression and liver function. Results The total effective rate of the observation group( 95.00%),which was significantly higher than that of the control group( 80.00%)( P <0.05). Regarding the incidence of adverse reactions,the observation group( 7.50%) was significantly lower than that in the control group( 25.00%)( P <0.05). One week after treatment,the concentration of bFGF and PCNA in the observation group was significantly lower than that in the control group( P <0.05). Conclusion When atenolol combined with dexamethasone applied in superficial IH patients,it can play a synergistic and antagonistic role,reduce adverse reactions,improve treatment effect,and significantly reduce the concentration of bFGF and PCNA.