血清Hcy,hs-CRP及IL-8水平与2型糖尿病合并抑郁症患者疗效的相关研究

Relationship between serum Hcy,hs-CRP and IL-8 levels and the efficacy of type 2 diabetes patients with depression

目的探讨血清中同型半胱氨酸(Hcy)、血清超敏C反应蛋白(hs-CRP)及白介素-8(IL-8)的水平与2型糖尿病(T2DM)合并抑郁症患者疗效的相关性。方法选取2015年12月-2017年12月经沧州市中心医院确诊为2型糖尿病(T2DM)合并抑郁症的110例患者作为研究对象。所有患者均采用西酞普兰联合利培同进行降糖抗抑郁治疗。治疗后采用抑郁自评量表(SDS)将患者分为优良组和一般组(n=55)。比较2组患者的一般临床资料,治疗前后的心理障碍程度和血糖变化情况。采用循环酶法测定2组患者的血清Hey水平,免疫比浊法测定hS-CRP水平,EUSA法检测血清IL-8水平。Pearson相关系数分析患者疗效情况与3种血清标志物水平的相关性。结果与治疗前相比,治疗后2组患者SDS和HAMD评分下降,差异有统计学意义(P均<0.05)。治疗后优良组SDS和HAMD评分显著低于一般组(P均<0.05)。2组患者血糖水平指标经治疗后有不同程度下降(P均<0.05),但2组间差异无统计学意义(P均>0.05)。治疗后2组患者的各标志物水平较治疗前均明显降低,且优良组标志物水平明显低于一般组,差异有统计学意义(P均<0.05)。治疗组患者3种血清标志物水平与SDS评分均呈正相关(P均<0.05);其中Hey与患者抑郁程度变化的相关性最强(P均<0.05)。结论治疗后血清中Hcy、h8-CUP及IL-8的水平与T2DM合并抑郁症患者的抑郁程度呈正相关,可能为改善T2DM合并抑郁症患者的疗效提供临床依据。

Objective To investigate the relationship between the levels of serum homocysteine(Hey),high-sensitivity C-reactive protein(hs-CRP)and interleukin-8(IL-8)and the efficacy of type 2 diabetes mellitus(T2DM)patients with depression.Methods A total of 110 T2DM patients with depression who were diagnosed in Cangzhou Central Hospital from December 2015 to December 2017 were enrolled.All patients were administrated with citalopram and risperidone for hypoglycemic and antidepressant treatment.According to self-rating depression scale(SDS)scores,the patients were divided into two groups(n=55):an excellent group and a general group.The two groups were compared for general information,the degree of psychological disorder and blood glucose changes before and after treatment.The levels of serum Hey were measured by the circulating enzymatic method.The levels of hs-CRP were determined by immunoturbidimetry.The levels of serum IL-8 were detected by ELISA.Furthermore,the Pearson product moment correlation coefficient was used to analyze the correlation between patient efficacy and the levels of the three serum markers.Results After treatment,both groups showed remarkable decreases in SDS and HAMD scores compared with those before treatment(P<0.05),where marked reduced SDS and HAMD scores were found in the excellent group in comparison with those in the general group(P<0.05).The levels of blood glucose were decreased in each group after treatment(P<0.05),but no statistical difference was found between the two groups(P>0.05).After treatment,the levels of each marker in the two groups were significantly lower than those before treatment,where marked decreases were found in the excellent group compared with the general group(P<0.05).There were positive correlations between the three serum markers and SDS scores in the treatment group(P<0.05),where Hey has the strongest correlation with depression change(P<0.05).Conclusions After treatment,the levels of serum Hey,hs-CRP and IL-8 were positively correlated with the degree of depression in T2DM patients with depression,which may provide evidence for improving the efficacy of T2DM patients with depression.