利多卡因致严重过敏和神经毒性反应

Severe Allergic and Neurotoxic Reactions Induced by Lidocaine

目的:探讨利多卡因局部浸润麻醉过程中严重过敏和神经毒性反应的防范与急救处理。方法:回顾性分析1例中老年女性肺结节患者采用0.5%利多卡因局部浸润麻醉,CT下定位肺结节,发生严重过敏和神经毒性反应的临床表现、治疗及处理经过。结果:经过积极观察病情和及时处理,该患者病情好转。结论:术前详细询问药物过敏史、加强患者的用药监护,以预防利多卡因所致严重过敏和神经毒性反应的发生,一旦发生该反应,应进行及时有效的抢救和处理。

OBJECTIVE: To explore the prevention and emergency treatment of severe allergic and neurotoxic reactions during local anesthesia of lidocaine. METHODS: Retrospective analysis was conducted on the clinical manifestations, treatment process of severe allergic and neurotoxic reactions in one case of middle-aged and elderly female pulmonary nodules under local infiltration anesthesia with 0.5% lidocaine and localization, and the pulmonary nodules was obtained under CT. RESULTS: After active observation and timely treatment, the patient’s condition improved. CONCLUSIONS: Ask about the history of drug allergy in detail before operation, and strengthen the medication monitoring of patients to prevent the occurrence of severe allergy and neurotoxic reactions caused by lidocaine.Once the reaction occurs, timely and effective rescue and treatment should be carried out.