关于糖尿病视网膜病变的表观遗传学进展

Progress in Epigenetics on Diabetic Retinopathy

糖尿病视网膜病变是目前全球第二大的致盲疾病,能够严重危害成年人的视力健康,表观遗传学作为环境和基因的作用中介,能够引起基因表达功能的变化而不改变基因序列,包括DNA甲基化、组蛋白修饰、非编码RNA等机制。有不少研究表明表观遗传学对于糖尿病视网膜病变有着重要的生理学意义,并且通过动物试验研究了具体的遗传靶点,有利于对糖尿病视网膜病变具体机制的理解。如果能够进一步深入研究,挖掘出更为准确具体的表观遗传学上的基因转录机制,将为糖尿病领域开辟新的纪元。

Diabetic retinopathy is the second largest blinding disease in the world, which can seriously harm the visual health of adults. Epigenetics acts as an intermediary between environment and genes, which can cause changes in gene expression function without changing gene sequences, including DNA methylation, histone modification, non-coding RNA and other mechanisms. Many studies have shown that epigenetics has important physiological significance for diabetic retinopathy, and specific genetic targets have been studied through animal experiments, which is conducive to the understanding of the specific mechanisms of diabetic retinopathy. If we can further study and dig out more accurate and specific epigenetic gene transcription mechanisms, it will open up a new era for diabetes.