降钙素原、巨噬细胞移动抑制因子和乳酸脱氢酶联合检测对儿童支原体肺炎的诊断价值

Diagnostic value of procalcitonin,macrophage migration inhibitory factor and lactate dehydrogenase in children with Mycoplasmal pneumonia

目的探讨降钙素原(PCT)、巨噬细胞移动抑制因子(MIF)和乳酸脱氢酶(LDH)联合检测对儿童支原体肺炎的诊断价值。方法选取2016年10月至2018年10月该院收治的儿童支原体肺炎患者60例(肺炎组)和体检健康儿童60例(对照组)作为研究对象。检测两组人员血清中PCT、MIF和LDH水平并采用受试者工作特征曲线(ROC曲线)下面积分析PCT、MIF和LDH对儿童支原体肺炎的诊断价值。结果儿童支原体肺炎患者血清中PCT、MIF和LDH水平均显著高于对照组,差异有统计学意义(t分别为62.74、17.72、33.65,P<0.05)。单向诊断儿童支原体肺炎与健康人群PCT、MIF和LDH的灵敏度分别为87%、83%、77%,特异度分为80%、87%、73%;PCT、MIF和LDH联合对儿童支原体肺炎的诊断的灵敏度为83.33%,特异度为81.67%,准确度为82.50%。结论 PCT、MIF和LDH可作为联合诊断儿童支原体肺炎的潜在标志物。

Objective To investigate the diagnostic value of procalcitonin(PCT),macrophage migration inhibitory factor(MIF)and lactate Dehydrogenase(LDH)in children with Mycoplasmal pneumonia.Methods 60 cases of children with Mycoplasma pneumonia admitted to the hospital from October 2016 to October 2018(pneumonia group)and 60 cases of healthy children(control group)were selected as research objects.Serum levels of PCT,MIF and LDH in the two groups were measured and the diagnostic value of PCT,MIF and LDH in children with Mycoplasma pneumonia was analyzed by using the area under the ROC curve.Results Serum levels of PCT,MIF and LDH in children with Mycoplasma pneumonia were significantly higher than those in the control group,the differences were statistically significant(t=62.74,17.72,33.65,P<0.05).One-way diagnosis of children with Mycoplasmal pneumonia and healthy people with PCT,MIF and LDH sensitivity of 87%,83%,77%,specificity of 80%,87%,73%;PCT,MIF and LDH combined with children with Mycoplasmal pneumonia The sensitivity of the diagnosis was 83.33%,the specificity was 81.67%,and the accuracy was 82.50%.Conclusion PCT,MIF and LDH can be used as potential markers for the combined diagnosis of Mycoplasmal pneumonia in children.