血清chemerin、vWF与SP-D水平与急性呼吸窘迫综合征预后的相关性研究

Study on the correlation between serum chemerin,vWF and SP-D expression level and prognosis of acute respiratory distress syndrome

目的研究血清脂肪因子趋化素(chemerin)、血管性假血友病因子(vWF)与肺泡表面活性物质相关蛋白D(SP-D)表达水平与急性呼吸窘迫综合征(ARDS)疾病预后的相关性。方法选取孝感市中心医院2017年1-12月收治120例ARDS患者作为研究对象,其中存活组患者90例,死亡组患者30例,对比两组患者血清chemerin、vWF与SP-D表达水平,同时对血清chemerin、vWF与SP-D对患者的预后进行相关性分析并对预警能力进行评估。结果死亡组患者血清chemerin(t=15.442,P=0.000)、vWF(t=8.556,P=0.000)与SP-D(t=8.239,P=0.000)表达水平显著高于生存组;死亡组患者急性生理学与慢性健康状况Ⅱ评分(APACHEⅡ)和序贯器官衰竭评分(SOFA)显著高于生存组,差异有统计学意义(t分别为11.097、11.638,P<0.05);患者的chemerin(r分别为1.231、1.411,P=0.000)、vWF(r分别为1.098、1.230,P=0.000)与SP-D(r分别为1.233、1.339,P=0.000)表达水平与APACHEⅡ和SOFA评分呈正相关,血清chemerin、vWF与SPD表达水平均可作为患者死亡的独立危险因素,受试者工作特征曲线分析显示,血清chemerin、vWF与SP-D的临界表达水平分别为16.11mg/L、216.71%、1.09ng/mL。结论血清chemerin、vWF与SP-D与患者的APACHEⅡ和SOFA评分呈正相关,血清chemerin、vWF与SP-D表达水平与ARDS疾病不良预后呈正相关。

Objective To study on the correlation between serum chemerin,vWF and SP-D expression level and prognosis of acute respiratory distress syndrome.Methods From January 2017 to December 2017,120 patients with acute respiratory distress were treated in ward of Xiaogan Central Hospital.Among them,90 patients were in survival group,30 patients were in death group,and the expression levels of chemerin,vWF and SP-D in serum were observed before admission.At the same time,the early warning ability of chemerin,vWF and SP-D in serum was evaluated.Results The expression levels of serum chemerin(t=15.442,P=0.000),vWF(t=8.556,P=0.000)and SP-D(t=8.239,P=0.000)in the dead group were significantly higher than those in the survival group;the APACHEⅡand SOFA scores in the dead group were significantly higher than those in the survival group,the difference was statistically significant(t was 11.097 and 11.638,respectively,P<0.05).The expression levels of chemerin(r was 1.231 and 1.411 respectively,P=0.000),vWF(r was1.098 and 1.230 respectively,P=0.000)and SP-D(r was 1.233 and 1.339 respectively,P=0.000)in the dead group were positively correlated with APACHE Ⅱand SOFA scores.The expression levels of serum chemerin,vWF and SP-D could be regarded as independent risk factors for death.ROC curve analysis showed that the expression levels of chemerin,vWF and SP-D in the The critical expression levels of serum chemerin,vWF and SP-D were 16.11 mg/L,216.71%and 1.09 ng/mL,respectively.Conclusion Serum chemerin,vWF and SP-D are positively correlated with APACHEⅡand SOFA scores.Serum chemerin,vWF and SP-D levels are positively correlated with poor prognosis of acute respiratory distress syndrome.