两种蓝光照射方式治疗新生儿黄疸患儿的临床价值体会

Clinical Value of Two Blue Light Irradiation Methods in the Treatment of Neonatal Jaundice

目的探讨新生儿黄疸行间断和持续蓝光照射的临床价值。方法方便选取该院于2016年5月-2017年5月期间,满足入选依据的新生儿黄疸患儿70例,以随机数字表法的形式将其平均分为观察组和对照组,每组各为35例。观察组行间断蓝光照射,对照组行持续蓝光照射。对比治疗后的总有效率、血清胆红素和粪胆素水平、胆红素变化指标以及不良反应发生率。结果①治疗后观察组总有效率82.8%和对照组77.1%对比差异无统计学意义(χ2=0.357 1,P>0.05);②观察组治疗后血清胆红素(40.5±10.5)μmol/L和粪胆素(168.3±22.6)mg/100 g,与对照组(43.6±12.3)μmol/L、(163.4±30.5)mg/100 g对比差异无统计学意义(t=1.134 0、0.763 6,P>0.05);③观察组不良反应发生率14.4%低于对照组34.3%,组间对比差异有统计学意义(χ2=5.185 2,P<0.05)。④两组患儿黄疸持续用时、首日胆红素下降、平均胆红素下降、首次排胎粪用时、胎粪排净用时对比,差异无统计学意义(t=0.851 6、0.230 9、0.075 7、1.283 3、0.638 3,P>0.05)。结论新生儿黄疸的主要发生原因为母乳性黄疸以及围产因素,通过间断和持续蓝光疗法,均能达到一定的治愈率,同时改善临床指标,但相比之下,间歇性蓝光照射的不良反应发生率低于持续性,临床推广价值存在。

Objective To investigate the clinical value of intermittent and continuous blue light irradiation in neonatal jaundice. Methods Convenient selected 70 children with neonatal jaundice who were eligible for inclusion in this hospital from May 2016 to May 2017 were randomly divided into observation group and control group, each group. Each of 35 cases. The observation group was intermittently exposed to blue light, and the control group was continuously irradiated with blue light. The total effective rate after treatment, serum bilirubin and cetillin levels, bilirubin change indicators, and incidence of adverse reactions were compared. Results 1.After treatment, the total effective rate of the observation group was 82.8% and the control group was 77.1%. There was no statistically significant difference (χ2=0.357 1, P>0.05). 2.The observation group received serum bilirubin (40.5±10.5)μmol/L and feces after treatment. There was no statistically significant difference between the biliary (168.3±22.6) mg/100 g and the control group (43.6±12.3)μmol/L,(163.4±30.5)mg/100 g(t=1.134 0, 0.763 6, P>0.05);3.The incidence of adverse reactions in the group was 14.4% lower than that in the control group (34.3%), and the difference between the groups was statistically significant(χ2=5.185 2, P<0.05). 4.There were no statistically significant differences in the duration of jaundice in the two groups, the decrease in bilirubin on the first day, the decrease in mean bilirubin, the use of meconium for the first time, and the net use of meconium(t=0.851 6, 0.230 9, 0.075 7, 1.283 3, 0.638 3, P>0.05). Conclusion The main cause of neonatal jaundice is breast milk jaundice and perinatal factors. Through intermittent and continuous blue light therapy, it can achieve a certain cure rate and improve clinical indicators, but in contrast, the intermittent blue light is poor. The incidence of response is lower than persistence, and clinical promotion value exists.