喹硫平与利培酮对以阴性症状为主的精神分裂症的治疗效果和不良反应

Therapeutic Effect and Adverse Reactions of Quetiapine and Risperidone on Schizophrenia with Negative Symptoms

目的分析喹硫平与利培酮对以阴性症状为主的精神分裂症的治疗效果和不良反应。方法该文研究对象为方便选取阴性症状为主的精神分裂症患者,研究例数一共200例,患者均采取抽签分组方式分为两组,收取时间在2016年2月—2017年2月之间,分为观察组一组(100例实施喹硫平治疗)、对照组一组(100例实施利培酮治疗),将两组患者各项指标进行对比。结果观察组精神分裂症患者的总有效率94.00%高于对照组患者80.00%(χ^2=8.9949,P<0.05);观察组患者的抑郁评分(15.01±0.11)分以及焦虑评分(14.25±1.02)分低于对照组患者(t=47.3817、46.4668,P<0.05);观察组患者的不良反应发生低于对照组患者(χ^2=8.0000,P<0.05);治疗后观察组BPRS评分(91.01±10.11)分低于对照组患者。差异有统计学意义(t=3.2548,P<0.05)。结论通过对以阴性症状为主的精神分裂症患者实施喹硫平后,取得显著效果,具有疗效显著、不良反应较低等特点。

Objective To analyze the therapeutic effects and adverse reactions of quetiapine and risperidone on schizophrenia with negative symptoms. Methods The conveniently selected study subjects were schizophrenia patients with negative symptoms. The total number of cases was 200. The patients were divided into two groups by lottery. The collection time was from February 2016 to February 2017, the observation group (100 patients treated with quetiapine) and the control group (100 patients treated with risperidone). Results The total effective rate of patients with schizophrenia in the observation group was 94.00% higher than that in the control group 80.00%(χ^2=8.994 9,P<0.05);the depression score (15.01±0.11)points and anxiety score (14.25±1.02)points in the observation group, lower than the control group (t=47.381 7,6.466 8,P<0.05);the adverse reactions of the observation group were lower than those of the control group (χ^2=8.000 0,P<0.05);The BPRS score of the post-observation group (91.01±10.11)points was lower than that of the control group.the difference was statistically significant (t=3.254 8,P<0.05). Conclusion After the implementation of quetiapine in patients with schizophrenia with negative symptoms, significant results have been achieved, with significant curative effect and low adverse reactions.