胰岛素泵连续皮下输注与静脉连续输注泵治疗糖尿病酮症酸中毒的疗效分析

Therapeutic Effect of Continuous Subcutaneous Infusion of Insulin Pump and Continuous Intravenous Infusion Pump on Diabetic Ketoacidosis

目的探讨胰岛素泵连续皮下输注与静脉连续输注泵治疗糖尿病酮症酸中毒(DKA)的疗效。方法方便选取该院2014年9月—2018年9月收治的DKA患者60例,随机抽签分为观察组和对照组,各30例,对照组给予人胰岛素注射液胰岛素泵连续皮下输注,观察组给予胰岛素泵静脉连续输注人胰岛素注射液治疗,比较两组疗效及血糖变化情况,记录并发症。结果治疗后两组间血糖差异无统计学意义(P>0.05);观察组血糖达标时间(5.28±1.63)h、血酮体转阴时间(9.92±4.35)h和尿酮体转阴时间(21.26±6.04)h、pH恢复时间(11.23±2.58)h及胰岛素平均用量(55.86±7.62)U均显著低于对照组(t=3.381、7.030、5.657、5.347、8.538,P<0.05);治疗期间两组并发症发生率比较差异无统计学意义(χ^2=0.577,P>0.05);治疗后观察组SOD(108.26±8.48)U/L、CAT(25.87±3.29)U/L、GSH-Px(97.38±10.24)U/L水平显著高于高于对照组(P<0.05)。结论胰岛素泵静脉连续输注泵较皮下连续输注疗效更好,能更快纠正酸中毒和酮体代谢,促进血糖更快达标,还能减少胰岛素用量和降低氧化损伤,且安全性好。

Objective To investigate the efficacy of continuous subcutaneous infusion of insulin pump and intravenous continuous infusion pump in the treatment of diabetic ketoacidosis (DKA). Methods Sixty patients with DKA admitted to our hospital from September 2014 to September 2018 were convenient selected and enrolled. The patients were randomly divided into observation group and control group, 30 cases in each group. The control group was given a continuous subcutaneous infusion of insulin injection insulin pump. The insulin pump was given intravenous infusion of human insulin injection, and the effects of the two groups and blood glucose changes were compared, and complications were recorded. Results There was no statistically significant difference in blood glucose between the two groups after treatment (P>0.05). The blood glucose compliance time (5.28±1.63) h, blood ketone body (9.92±4.35)h and urine ketone body negative time (21.26±6.04) h, pH recovery time (11.23±2.58) h and the average insulin dosage (55.86±7.62)U were significantly lower than the control group (t=3.381,7.030,5.657,5.347,8.538, P<0.05);During the treatment, there was no statistically significant difference in the incidence of complications between the two groups (χ^2=0.577, P>0.05). After treatment, the observation group had SOD (108.26±8.48) U/L, CAT (25.87±3.29)U/L, GSH-Px (97.38±10.24) U/L level was significantly higher than the control group (P<0.05). Conclusion Insulin pump continuous infusion pump is better than subcutaneous continuous infusion. It can correct acidosis and ketone metabolism faster, promote blood glucose to reach the standard faster, reduce insulin dosage and reduce oxidative damage, and it is safe.