特布他林联合布地奈德治疗小儿哮喘急性发作效果研究

Effect of Terbutaline Combined with Budesonide on Acute Asthma Attack in Children

目的对小儿哮喘急性发作治疗中特布他林联合布地奈德的效果进行探讨。方法方便选择该该院2017年7月-2018年6月收治的小儿哮喘患儿120例,依据随机数字表法分为实验组和常规组,各60例。常规组接受特布他林治疗,实验组联合应用特布他林和布地奈德治疗,统计并对比两组胸闷缓解时间、气急缓解时间、哮鸣音消失时间、咳嗽缓解时间、临床疗效、肺功能改善情况。结果治疗后实验组胸闷缓解时间(3.2±0.9)d、气急缓解时间(2.6±0.6)d、哮鸣音消失时间(4.6±0.8)d、咳嗽缓解时间(5.3±1.2)d显著低于常规组的(5.1±1.3)d、(3.9±1.0)d、(6.9±1.1)d、(8.5±2.1)d,差异有统计学意义(t=7.104,P=0.000;t=5.342,P=0.000;t=6.657,P=0.000;t=7.467,P=0.000)。实验组PEF (9.8±1.2)%、FEV1(199.8±25.1)mL、FEV1/FVC(99.2±16.7)%,显著高于常规组(7.7±1.1)%、(175.7±25.2)mL、(77.5±13.5)%,差异有统计学意义(t=5.362,P=0.000;t=6.767,P=0.000;t=6.783,P=0.000)。实验组治疗总有效率91.7%,显著高于常规组的73.3%,差异有统计学意义(t=7.394,P=0.000)。结论应用特布他林联合布地奈德治疗小儿哮喘急性发作患儿,能够使其肺功能得到有效改善,并快速减轻患者症状,具有较高推广价值。

Objective To investigate the effect of terbutaline combined with budesonide in the treatment of acute asthma attack in children. Methods A total of 120 children with asthma in our hospital from July 2017 to June 2018 were convenient enrolled. The patients were divided into experimental group and routine group according to the random number table method, with 60 cases in each group. The routine group received terbutaline treatment. The experimental group was treated with terbutaline and budesonide. The two groups were compared: chest tightness relief time, air urgency time, wheezing time, cough remission time, clinical efficacy, lung functional improvement. Results After treatment, the chest tightness relief time (3.2±0.9) d, air urgency remission time (2.6±0.6) d, wheezing disappearance time (4.6±0.8) d, and cough remission time (5.3±1.2) d were significantly lower than the conventional group (5.1±1.3)d,(3.9±1.0)d,(6.9±1.1)d,(8.5±2.1)d,the difference was statistically significant(t=7.104, P=0.000;t=5.342, P=0.000;t=6.657, P=0.000;t=7.467, P=0.000). The experimental group had PEF (9.8±1.2)%, FEV1 (199.8±25.1)mL, and FEV1/FVC (99.2±16.7)%, which was significantly higher than the conventional group (7.7±1.1)%,(175.7±25.2)mL,(77.5± 13.5)%,the difference was statistically significant(t=5.362, P=0.000;t=6.767, P=0.000;t=6.783, P=0.000). The total effective rate of the experimental group was 91.7%, which was significantly higher than that of the conventional group 73.3%,the difference was statistically significant(t=7.394, P=0.000). Conclusion The combination of terbutaline and budesonide in children with acute asthma attack can effectively improve their lung function and rapidly reduce the symptoms of patients, which has a high promotion value.