卵巢浆液性腺癌组织锌指蛋白变体(Ciz1-V蛋白)的表达与患者预后的相关性研究

Correlation between the Expression of Ciz1-V in Ovarian Serous Adenocarcinoma and Prognosis of Patients

目的研究锌指蛋白变体V(Ciz1-V蛋白)表达水平在卵巢浆液性腺癌患者预后评估中的临床意义。方法选取2005~2014年扬州大学医学院附属扬州市妇幼保健院和南京医科大学附属逸夫医院40例卵巢浆液性腺癌患者,回顾性分析FIGO分期和肿瘤分级对其预后的影响,同时采用免疫组织化学法检测Ciz1-V蛋白的表达,绘制Kaplan-Meier生存曲线,筛选预后相关因素。结果Kaplan-Meier生存曲线显示,该实验中FIGO分期与生存期之间不具有统计学意义(P=0.08),高、低级别卵巢浆液性腺癌患者之间的差异有统计学意义(P=0.035)。在40例卵巢浆液性腺癌患者中,Ciz1-V蛋白低表达组预后明显较Ciz1-V蛋白高表达组预后差,差异有统计学意义(P=0.016)。结论卵巢浆液性腺癌肿瘤分级越高,其生物学行为愈差,生存率越低。当患者肿瘤分级相同时,检测Ciz1-V蛋白的表达水平对于预测患者预后有价值。

Objective To research the expression of Ciz1-V protein in patients with ovarian serous adenocarcinoma.Methods Specimens of 40 patients with ovarian serous adenocarcinoma in Yangzhou Maternal and Child Care Service Centre of the Affiliated Hospital of Medical College of Yangzhou University,and Yifu Hospital Affiliated to Nanjing Medical University were selected from 2005 to 2014.A retrospective analysis was made of FIGO staging and tumor grading on the prognosis,meanwhile,the expression of Ciz1-V protein was detected by immunohistochemical method and the prognostic factors were screened by Kaplan-Meier survival curve.Results The Kaplan-meier survival curve showed that there was no significant difference between the FIGO staging and the survival time(P=0.08)and the prognosis of patients with low grade ovarian serous adenocarcinoma was significantly better than patients with high-grade ovarian serous adenocarcinoma(P=0.035).In 40 patients with ovarian serous adenocarcinoma,patients with higher level of Ciz1-V protein had a better survival rate than patients with lower level of Ciz1-V protein(P=0.016).Conclusion The higher the tumor grading,the worse the biological behavior and the lower the survival rate of ovarian serous adenocarcinoma.When the tumor grading is the same,the expression of Ciz1-V protein is valuable to predict the prognosis of patients.