复发性卵巢癌患者血清NDRG4水平表达与临床特征及预后的相关性研究

Correlation between Serum NDRG4 Expression and Clinical Features and Prognosis in Patients with Recurrent Ovarian Cancer

目的探讨复发性卵巢癌(recurrent ovarian cancer,ROC)患者血清抑癌基因N-myc下游调节因子4(N-myc downscream regulated gene 4,NDRG4)蛋白质的表达水平及其对预后的影响。方法通过电化学发光法检测课题组2010年1月~2014年12月所收集到的147例ROC患者血清NDRG4蛋白质的表达水平,并分析其蛋白质水平与ROC患者临床特征之间的关联。结果NDRG4蛋白在ROC患者不同临床分期患者之间的表达差异有统计学意义(F=20.311,P<0.001),高NDRG4蛋白水平和临床分期较晚呈正相关(γ=0.326,P<0.001),且NDRG4蛋白质水平与ROC患者的吸烟(χ^2=10.600,P=0.001)、饮酒(χ^2=5.033,P=0.028)、肿瘤临床分期(χ^2=9.918,P=0.003)、T分期(χ^2=33.344,P<0.001)、N分期(χ^2=12.392,P<0.001)和M分期(χ^2=6.714,P=0.013)相关。结论NDRG4在ROC中发挥抑癌作用,血清NDRG4水平较高的ROC患者预后较好。

Objective To explore the expression level and effect of NDRG4 protein in serum of patients with recurrent ovarian cancer(ROC).Methods Detected the expression level of NDRG4 protein in the serum of recurrent ROC patients using electrochemiluminescence,and analysed the correlation of the NDRG4 protein level and clinical characteristics.Results NDRG4 protein was differently expressed in different clinical stage of recurrent ovarian cancer(ROC)patients(F=20.311,P<0.001),and the high level of NDRG4 protein was correlated with the late clinical stage(γ=0.326,P<0.001)of the patients.NDRG4 protein level was correlated with smoking(χ^2=10.600,P=0.001),drinking(χ^2=5.033,P=0.028),clinical stage(χ^2=9.918,P=0.003),T stage(χ^2=33.344,P<0.001),N stage(χ^2=12.392,P<0.001),M stage(χ^2=6.714,P=0.013).Conclusion NDRG4 acted as a tumor suppressor in ROC patients with higher level of serum NDRG4 protein would had a better prognosis.