西京医院性病门诊7712例尖锐湿疣患者疣体组织HPV型别回顾性分析

Retrospective Analysis of Verrucous Tissue 7 712 Patients with HPV Types Condyloma Acuminate in Venereal Outpatient of Xijing Hospital

目的回顾性研究西京医院性病门诊尖锐湿疣患者HPV基因型的感染特点,为尖锐湿疣的防治提供理论依据。方法收集2010年9月~2018年9月7712例西京医院性病门诊尖锐湿疣患者疣体组织,利用反向分子点杂交方法进行HPV基因分型检测,最后统计分析检测结果和临床资料。结果7712例患者中男性4935例,女性2777例,年龄分布多为青壮年,以20~29岁最多,其中0~9岁及50岁以上患者664例(8.61%)。7712例患者中有50例未检测出任何HPV型别,其余7 662例患者共检测出23种型别,检出频次排名依次为HPV6,11,16,43,52,42,58,51,59和56型,单一基因型感染占58.98%(4519/7662),多种基因型感染占41.02%(3143/7 662),其中二重感染最多占60.77%(1 910/3 143),最多可见同时感染14个基因型。低危型感染占60.66%(4648/7662),低高混合型占32.17%(2465/7662),高危型占7.17%(549/7662)。结论陕西省尖锐湿疣患者男性多于女性,儿童及老年患者不容忽视。HPV感染特点以单一型和低危型为主,感染型别主要为HPV6,11,16,43,52,42,58,51,59和56型,亦有部分患者未检测出任何HPV型别,有待于进一步研究。

Objective To study retrospective the HPV genotype characteristics of condyloma acuminatum in the venereal outpatient of Xijing Hospital so as to provide theoretical basis for the prevention and treatment of condyloma acuminata.Methods From September 2010 to September 2018,Tissue of 7 712 cases of condyloma condylus in the venereal outpatient of Xijing Hospital were collected and HPV gene typed by reverse dot hybridization method,and analyzed the test results and clinical data finally.Results 7 712 cases included males 4 935 and females 2 777.The age distribution of patients was mostly young adults.The number of patients with 20~29 years old was the highest,and the number of 0~9 and above 50 years old was about 664(8.61%).50 cases did not detect any type,and 7 662 cases were detected 23 HPV genotypes of the 7 712 cases.HPV6,11,16,43,52,42,58,51,59 and 56 were rank in the top 10.Single genotype infection rate of HPV was 58.98%(4 519/7 662)and multiple genotypes infection rate of HPV was 41.02%(3 143/7 662),of which the highest number was the secondary infections up to 60.77%(1 910/3 143),and HPV types of someone could be detected up to 14.Low-risk type accounts for 60.66%(4 648/7 662).Low and high mixed accounts for 32.17%(2 465/7 662),and high-risk types accounted for 7.17%(549/7 662).Conclusion The condyloma acuminatum patient was more male than female,children and old age should be valued.The Single genotype infection and low-risk HPV types were the main factors.Infection types were mainly HPV 6,11,16,43,52,42,58,51,59 and 56.There were also some patients who had not detected any HPV type and further study is needed.