hnRNPK蛋白功能与肿瘤的研究进展

Research Progress in Function and Role of hnRNPK in Tumors

核内不均一核糖核蛋白K(hnRNPK)是一种与DNA和RNA结合,调控多种基因表达和翻译的多功能蛋白分子。hnRNPK在RNA转录、翻译、剪切和稳定等生物过程中发挥重要作用,参与肿瘤的增殖、凋亡、迁移和侵袭等生物学功能。hnRNPK在多种肿瘤中异常表达,可作为癌基因或抑癌基因参与肿瘤发生、发展和转移等多种生物过程。尤其近年新发现肿瘤相关的hnRNPK-ncRNAs调控靶基因表达参与肿瘤发生发展,深入研究hnRNPK相关的ncRNAs在肿瘤中的表达情况、调控机制和生物学功能可为临床肿瘤诊断、治疗和预后提供新靶点。

Heterogeneous nuclear ribonucleoprotein K( hnRNPK) is a multifunctional protein,which is a DNA and RNAbinding protein,and is closely involved in regulation of the expression and translation of various genes. hnRNPK plays an important role in biological processes,such as RNA transcription,translation,splicing and stabilization. It plays an important role in the proliferation,apoptosis,migration and invasionof various tumors. hnRNPK is abnormally expressed in various tumors,as oncogene or tumor suppressor gene to participate in many biological processes,such as tumorigenesis,development and metastasis. In recent years,it’s discovered that the tumor-related hnRNPK-ncRNAs regulate target gene expression to participate in tumor biological processes,and further study on the expression,regulatory mechanism and biologi-cal function of hnRNPK-related ncRNAs in tumors can provide new targets for the clinical diagnosis,treatment and prognosis of tumors.