颅内动脉瘤破裂风险评估的研究进展

Advances in Risk Assessment of Intracranial Aneurysm Rupture

颅内动脉瘤破裂的危险因素主要与动脉瘤的形态学(大小、形状及位置)、血流动力学(流入射流、壁面剪应力)、壁内的炎症(动脉瘤壁的炎症程度)及患者的临床因素(年龄和性别、高血压和吸烟史、女性绝经史)等相关。目前,三维形态学参数、蝶骨嵴近端征象、分子影像学判断炎症和四维CT血管造影技术检测动脉瘤壁的异常搏动也成为预测颅内动脉瘤破裂风险的因素。这些新的预测因素,在预测颅内动脉瘤的破裂风险中也起到重要作用。

The risk factors for rupture of intracranial aneurysms are mainly related to the morphology( size,shape and location) of aneurysms,hemodynamics( flow incident,wall shear stress),inflammation in the wall( inflammation degree of the aneurysm wall) and patient clinical factors( age and gender,hypertension and smoking history,female menopause history). At present,three-dimensional morphological parameters,proximal sphenoid ridge signs,molecular imaging to determine inflammation and four-dimensional CT angiography to detect abnormal pulsation of aneurysm wall have also become factors in predicting the rupture risk of intracranial aneurysm,playing important roles in the prediction.