足三里注射胃复安治疗慢性肾衰竭恶心呕吐临床研究

Clinical Study of Zusanli Injection of Metoclopramide in the Treatment of Chronic Renal Failure with Nausea and Vomiting

目的:观察足三里注射胃复安治疗慢性肾衰竭(CRF)恶心呕吐的疗效。方法:选取符合纳入标准的CRF患者61例,随机分为观察组31例和对照组30例。观察组予足三里穴位注射胃复安10mg,对照组给予常规肌肉注射胃复安10 mg。观察两组疗效、症状缓解时间,并比较不同证型之间发生恶心呕吐的情况。结果:不论观察组还是治疗组,脾肾阳虚兼湿浊证与脾肾气虚兼湿浊证发生恶心呕吐的患者均多于肝肾阴虚兼血瘀证,差异有统计学意义(P<0.05);观察组总有效率96.77%,高于对照组总有效率93.33%,但差异无统计学意义(P>0.05);观察组于(1±2.76)min后起效,对照组于(2±1.78)min后起效,差异有统计学意义(P<0.05)。结论:与肌肉注射胃复安相比,足三里注射胃复安疗效更佳,缓解症状时间更短。

Objective:To observe the efficacy of Zusanli injection of metoclopramide in the treatment of (CRF) with nausea and vomiting in chronic renal failure.Methods:61 patients with CRF were randomly divided into observation group (n = 31) and control group (n=30).Observation group was given Zusanli acupoint injection of metoclopramide for 10mg,control group routine intramuscular injection of metoclopramide for 10mg.Observe the curative effect,symptom relief time,and compare the nausea and vomiting between different syndromes.Results:in both the observation group and the treatment group? there were more cases of nausea and vomiting in the syndrome of spleen and kidney yang deficiency combined with dampness turbidity and spleen kidney qi deficiency combined with dampness turbid syndrome than in the liver and kidney yin deficiency syndrome.The total effective rate of the observation group was 96.77,which was higher than that of the control group (93.33)(P<0.05).The effect in the observation group was (1±2.76) min,and that in the control group was (2±1.78) min.The difference was statistically significant (P<0.05).Conclusion :compared with intramuscular injection of metoclopramide? Zusanli injection of metoclopramide has better effect and shorter time to relieve symptoms.